The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of
muscle loss that occurs in the elderly. Since then, a broader definition comprising not only …

Loss of muscle proteins is a deleterious consequence of chronic kidney disease (CKD) that
causes a decrease in muscle strength and function, and can lead to a reduction in quality of …

Background: Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease
(COPD) and it has important clinical implications, such as reduced exercise tolerance …

In patients with chronic kidney disease (CKD), loss of cellular proteins increases the risks of
morbidity and mortality. Persistence of muscle protein catabolism in CKD results in striking …

Protein energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and
is associated with adverse clinical outcomes, especially in individuals receiving …

Sepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host
response to infection”. Contrary to the older definitions, the current one not only focuses on …

The recent research findings concerning syndromes of muscle wasting, malnutrition, and
inflammation in individuals with chronic kidney disease (CKD) or acute kidney injury (AKI) …

Bicarbonate supplementation preserves renal function in experimental chronic kidney
disease (CKD), but whether the same benefit occurs in humans is unknown. Here, we …

All intracellular proteins and many extracellular proteins are continually “turning over;” ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other
systemic diseases that results primarily from accelerated protein degradation by the …