The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Correlates of protection (CoPs) are increasingly important in the development and licensure
of vaccines. Although the study of CoPs was initially directed at identifying a single immune …

Tumours often contain B cells and plasma cells but the antigen specificity of these
intratumoral B cells is not well understood,,,,,,–. Here we show that human papillomavirus …

Shingles is a painful, blistering rash caused by reactivation of latent varicella-zoster virus
(VZV) and most frequently occurs in elderly and immunocompromised individuals. Currently …

Impaired vaccine responses in older individuals are associated with alterations in both the
quantity and quality of the T-cell compartment with age. As reviewed herein, the T-cell …

Human papillomaviruses (HPVs) are the causative agent of several anogenital cancers as
well as head and neck cancers, with HPV+ head and neck squamous cell carcinoma …

In December 2019, a pneumonia outbreak, caused by severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2), was first identified in Wuhan, China and presented a major …

Vaccines are among the most cost-effective public health interventions for preventing
infection-induced morbidity and mortality, yet much remains to be learned regarding the …

Two herpes zoster (HZ) vaccines licensed in the United States are recommended by the
Advisory Committee on Immunization Practices (ACIP):(i) live-attenuated vaccine (ZVL) …

The clinical presentation of varicella in unvaccinated persons, with skin vesicles and scabs,
has facilitated the use of rapid diagnostic methods for confirming disease. Polymerase chain …