Pathogenic cellular and molecular mediators in lupus nephritis
C Mohan, T Zhang, C Putterman - Nature Reviews Nephrology, 2023 - nature.com
Kidney involvement in patients with systemic lupus erythematosus—lupus nephritis (LN)—is
one of the most important and common clinical manifestations of this disease and occurs in …
one of the most important and common clinical manifestations of this disease and occurs in …
An update on lupus animal models
Spontaneous and induced models of lupus models are useful tools for the study of the cause
of the disease, identify therapeutic targets and screen treatments in preclinical studies. Each …
of the disease, identify therapeutic targets and screen treatments in preclinical studies. Each …
Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus
In lupus, Toll-like receptor 7 (TLR7) and TLR9 mediate loss of tolerance to RNA and DNA,
respectively. Yet, TLR7 promotes disease, while TLR9 protects from disease, implying …
respectively. Yet, TLR7 promotes disease, while TLR9 protects from disease, implying …
[HTML][HTML] B cell–intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice
HA Cosgrove, S Gingras, M Kim, S Bastacky, JS Tilstra… - JCI insight, 2023 - ncbi.nlm.nih.gov
The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic
lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is enhanced when the …
lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is enhanced when the …
Toll-like receptor 9 deficiency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammation
Toll-like receptors (TLRs) play pivotal roles in inflammation and provide important links
between the immune and skeletal systems. Although the activation of TLRs may affect …
between the immune and skeletal systems. Although the activation of TLRs may affect …
New aspects of kidney fibrosis–from mechanisms of injury to modulation of disease
Organ fibrogenesis is characterized by a common pathophysiological final pathway
independent of the underlying progressive disease of the respective organ. This makes it …
independent of the underlying progressive disease of the respective organ. This makes it …
B cell–intrinsic TLR9 expression is protective in murine lupus
JS Tilstra, S John, RA Gordon, C Leibler… - The Journal of …, 2020 - Am Soc Clin Investig
Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus
erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the …
erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the …
TLR7/TLR9-and B cell receptor-signaling crosstalk: promotion of potentially dangerous B cells
AN Suthers, S Sarantopoulos - Frontiers in immunology, 2017 - frontiersin.org
B cells are capable of receptor-mediated responses to foreign antigens. Recognition of
microbial-derived nucleic acid (NA) by toll-like receptors (TLRs) 7 and 9 in B cells has been …
microbial-derived nucleic acid (NA) by toll-like receptors (TLRs) 7 and 9 in B cells has been …
Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
AL Gavin, D Huang, TR Blane, TC Thinnes… - Nature …, 2021 - nature.com
Abstract Phospholipase D3 (PLD3) and PLD4 polymorphisms have been associated with
several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA …
several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA …
cGAS-STING pathway does not promote autoimmunity in murine models of SLE
M Motwani, J McGowan, J Antonovitch… - Frontiers in …, 2021 - frontiersin.org
Detection of DNA is an important determinant of host-defense but also a driver of
autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in DNAseII or III …
autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in DNAseII or III …