Mechanisms of fungal dissemination

AB Strickland, M Shi - Cellular and Molecular Life Sciences, 2021 - Springer
Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

Leukotrienes: underappreciated mediators of innate immune responses

M Peters-Golden, C Canetti, P Mancuso… - The Journal of …, 2005 - journals.aai.org
Leukotrienes are bronchoconstrictor and vasoactive lipid mediators that are targets in the
treatment of asthma. Although they are increasingly recognized to exert broad …

Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut

M Raffatellu, RL Santos, DE Verhoeven, MD George… - Nature medicine, 2008 - nature.com
Salmonella typhimurium causes a localized enteric infection in immunocompetent
individuals, whereas HIV-infected individuals develop a life-threatening bacteremia. Here …

Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study

DR Boulware, DB Meya, TL Bergemann… - PLoS …, 2010 - journals.plos.org
Background Although antiretroviral therapy (ART) improves survival in persons with
cryptococcal meningitis (CM) and AIDS, ART frequently elicits HIV immune reconstitution …

Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome

DR Boulware, SC Bonham, DB Meya… - The Journal of …, 2010 - academic.oup.com
Abstract Background. Cryptococcal meningitis (CM)-related immune reconstitution
inflammatory syndrome (IRIS) complicates antiretroviral therapy (ART) in 20%–40% of ART …

5-lipoxygenase and FLAP

M Peters-Golden, TG Brock - Prostaglandins, leukotrienes and essential …, 2003 - Elsevier
The initial steps in the biosynthesis of leukotrienes from arachidonic acid are carried out by
the enzyme 5-lipoxygenase (5-LO). In intact cells, the helper protein 5-LO activating protein …

[HTML][HTML] Oxidative responses and fungal infection biology

A Warris, ER Ballou - Seminars in cell & developmental biology, 2019 - Elsevier
Oxidative responses and fungal infection biology - ScienceDirect Skip to main contentSkip to
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Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages

J Casas, C Meana, E Esquinas… - The Journal of …, 2009 - journals.aai.org
Eicosanoids are a broad family of lipids that play a critical role in host defense against
bacterial and fungal infections. The first enzyme in the metabolic pathway for the generation …

Th17 cells, HIV and the gut mucosal barrier

S Dandekar, MD George… - Current opinion in HIV and …, 2010 - journals.lww.com
A better understanding of the role of Th17 CD4+ cells in the generation of mucosal immune
responses to enteric pathogens and maintenance of the intestinal epithelial integrity in HIV …

The role of leukotrienes in airway inflammation

Y Ogawa, WJ Calhoun - Journal of allergy and clinical immunology, 2006 - Elsevier
Cysteinyl leukotrienes (cysLTs) are a class of closely structurally related lipid molecules,
originally described as slow-reacting substance of anaphylaxis, with a myriad of biologic …