[HTML][HTML] Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease
Variation in lung alveolar development is strongly linked to disease susceptibility. However,
underlying cellular and molecular mechanisms are difficult to study in humans. We have …
underlying cellular and molecular mechanisms are difficult to study in humans. We have …
Decoding gene regulation in the fly brain
The Drosophila brain is a frequently used model in neuroscience. Single-cell transcriptome
analysis,,,,–, three-dimensional morphological classification and electron microscopy …
analysis,,,,–, three-dimensional morphological classification and electron microscopy …
DamID as a versatile tool for understanding gene regulation
The interaction of proteins and RNA with chromatin underlies the regulation of gene
expression. The ability to profile easily these interactions is fundamental for understanding …
expression. The ability to profile easily these interactions is fundamental for understanding …
[HTML][HTML] SMCHD1 merges chromosome compartments and assists formation of super-structures on the inactive X
Mammalian chromosomes are partitioned into A/B compartments and topologically
associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct …
associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct …
Dam it's good! DamID profiling of protein‐DNA interactions
GN Aughey, TD Southall - Wiley Interdisciplinary Reviews …, 2016 - Wiley Online Library
The interaction of proteins with chromatin is fundamental for several essential cellular
processes. During the development of an organism, genes must to be tightly regulated both …
processes. During the development of an organism, genes must to be tightly regulated both …
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration
L Aloia, MA McKie, G Vernaz, L Cordero-Espinoza… - Nature cell …, 2019 - nature.com
Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to
regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that …
regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that …
[HTML][HTML] Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation
Gut microbes play important roles in host physiology; however, the mechanisms underlying
their impact remain poorly characterized. Here, we demonstrate that microbes not only …
their impact remain poorly characterized. Here, we demonstrate that microbes not only …
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling
The balance between self‐renewal and differentiation in human foetal lung epithelial
progenitors controls the size and function of the adult organ. Moreover, progenitor cell gene …
progenitors controls the size and function of the adult organ. Moreover, progenitor cell gene …
[HTML][HTML] Mitotic implantation of the transcription factor prospero via phase separation drives terminal neuronal differentiation
Compacted heterochromatin blocks are prevalent in differentiated cells and present a barrier
to cellular reprogramming. It remains obscure how heterochromatin remodeling is …
to cellular reprogramming. It remains obscure how heterochromatin remodeling is …
[HTML][HTML] Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains
Eukaryotic chromosomes are folded into hierarchical domains, forming functional
compartments. Nuclear periphery and nucleolus are two nuclear landmarks contributing to …
compartments. Nuclear periphery and nucleolus are two nuclear landmarks contributing to …