Variation in lung alveolar development is strongly linked to disease susceptibility. However,
underlying cellular and molecular mechanisms are difficult to study in humans. We have …

The Drosophila brain is a frequently used model in neuroscience. Single-cell transcriptome
analysis,,,,–, three-dimensional morphological classification and electron microscopy …

The interaction of proteins and RNA with chromatin underlies the regulation of gene
expression. The ability to profile easily these interactions is fundamental for understanding …

Mammalian chromosomes are partitioned into A/B compartments and topologically
associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct …

The interaction of proteins with chromatin is fundamental for several essential cellular
processes. During the development of an organism, genes must to be tightly regulated both …

Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to
regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that …

Gut microbes play important roles in host physiology; however, the mechanisms underlying
their impact remain poorly characterized. Here, we demonstrate that microbes not only …

The balance between self‐renewal and differentiation in human foetal lung epithelial
progenitors controls the size and function of the adult organ. Moreover, progenitor cell gene …

Compacted heterochromatin blocks are prevalent in differentiated cells and present a barrier
to cellular reprogramming. It remains obscure how heterochromatin remodeling is …

Eukaryotic chromosomes are folded into hierarchical domains, forming functional
compartments. Nuclear periphery and nucleolus are two nuclear landmarks contributing to …