Protozoan parasites continue to cause a significant health and economic burden worldwide.
As infectious organisms, they pose unique and difficult challenges due to a level of …

Simple Summary Multicellular organisms develop from a single cell into a multitude of cell
types organized in tissues and organs. Organisms grow at a coordinated pace until reaching …

Defining all sites for a post-translational modification in the cell, and identifying their
upstream modifying enzymes, is essential for a complete understanding of a modification's …

Retinoic acid receptor–related orphan receptor α (RORα) is a transcription factor involved in
nuclear gene expression and a known tumor suppressor. RORα was the first identified …

Diarrheal disease caused by Giardia duodenalis is highly prevalent, causing over 200
million cases globally each year. The processes that drive parasite virulence, host immune …

Recent developments in mass spectrometry (MS) instruments and data acquisition modes
have aided multiplexed, fast, reproducible and quantitative analysis of proteome profiles, yet …

Histone post-translational modifications are extensively studied for their role in regulating
gene transcription and cellular environmental adaptation. Research into these modifications …

Dynamic posttranslational modifications to canonical histones that constitute the
nucleosome (H2A, H2B, H3, and H4) control all aspects of enzymatic transactions with DNA …

Post‐translational methylation of proteins, which occurs in arginines and lysines, modulates
several biological processes at different levels of cell signaling. Recently, methylation has …

Post-translational methylation of proteins, which occurs in arginines and lysines, modulates
several biological processes at different levels of cell signaling. Recently, methylation has …