Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid
tumours relies on the accumulation, proliferation and persistency of T cells at the tumour site …

The efficacy of T-cell therapy is inhibited by various tumor-associated immunosuppressive
ligands and soluble factors. Such inhibitory signals turn specific T-cell signaling pathways …

The differentiation of αβT cells from thymic precursors is a complex process essential for
adaptive immunity. Here we exploited the breadth of expression data sets from the …

Programmed cell death protein 1 (PD-1) immune checkpoint blockade therapy has
revolutionized cancer treatment. Although PD-1 blockade is effective in a subset of patients …

Diacylglycerol (DAG) is an important lipid that is both an intermediate in lipid biosynthetic
pathways and can act as a signaling lipid. The majority of signaling DAG is generated by …

Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

Ras guanyl nucleotide releasing proteins (RasGRPs) are guanyl nucleotide exchange
factors that activate Ras and related GTPases such as Rap. Like Sos proteins, RasGRPs …

T cells play important roles in autoimmune diseases and cancer. Following the cloning of the
T cell receptor (TCR), the race was on to map signaling proteins that contributed to T cell …