Vaccines for visceral leishmaniasis: A review

K Jain, NK Jain - Journal of immunological methods, 2015 - Elsevier
Visceral leishmaniasis, which is also known as Kala-Azar, is one of the most severely
neglected tropical diseases recognized by the World Health Organization (WHO). The threat …

A brief review on the strategy of developing SPR-based biosensors for application to the diagnosis of neglected tropical diseases

DEP Souto, J Volpe, CC Gonçalves, CHI Ramos… - Talanta, 2019 - Elsevier
The phenomenon of surface plasmon resonance (SPR) through optical sensors was
developed from initial studies involving excitation of surface plasmons on metallic …

A recombinant chimeric protein-based vaccine containing T-cell epitopes from amastigote proteins and combined with distinct adjuvants, induces immunogenicity and …

DP Lage, DL Vale, FP Linhares, CS Freitas… - Vaccines, 2022 - mdpi.com
Currently, there is no licensed vaccine to protect against human visceral leishmaniasis (VL),
a potentially fatal disease caused by infection with Leishmania parasites. In the current …

Novel Recombinant Multiepitope Proteins for the Diagnosis of Asymptomatic Leishmania infantum-Infected Dogs

AR Faria, L de Castro Veloso… - PLoS neglected …, 2015 - journals.plos.org
Background Visceral leishmaniasis is the most severe form of leishmaniasis. Worldwide,
approximately 20% of zoonotic human visceral leishmaniasis is caused by Leishmania …

A candidate vaccine for human visceral leishmaniasis based on a specific T cell epitope-containing chimeric protein protects mice against Leishmania infantum …

DP Lage, PAF Ribeiro, DS Dias, DVC Mendonça… - npj Vaccines, 2020 - nature.com
Leishmaniases are neglected diseases caused by infection with Leishmania parasites and
there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic …

A TLR9-adjuvanted vaccine formulated into dissolvable microneedle patches or cationic liposomes protects against leishmaniasis after skin or subcutaneous …

JS Lanza, S Vucen, O Flynn, A Donadei… - International Journal of …, 2020 - Elsevier
Re-emergence and geographic expansion of leishmaniasis is accelerating efforts to develop
a safe and effective Leshmania vaccine. Vaccines using Leishmania recombinant antigens …

Proteins selected in Leishmania (Viannia) braziliensis by an immunoproteomic approach with potential serodiagnosis applications for tegumentary leishmaniasis

MC Duarte, DC Pimenta… - Clinical and Vaccine …, 2015 - Am Soc Microbiol
The serodiagnosis of human tegumentary leishmaniasis (TL) presents some problems, such
as the low level of antileishmanial antibodies found in most of the patients, as well as the …

Visceral leishmaniasis: advancements in vaccine development via classical and molecular approaches

S Joshi, K Rawat, NK Yadav, V Kumar… - Frontiers in …, 2014 - frontiersin.org
Visceral leishmaniasis (VL) or kala-azar, a vector-borne protozoan disease, shows
endemicity in larger areas of the tropical, subtropical and the Mediterranean countries. WHO …

Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis

MC Duarte, DP Lage, VT Martins… - Revista da Sociedade …, 2016 - SciELO Brasil
Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide.
Although chemotherapy has been widely used to treat this disease, problems related to the …

Visceral leishmaniasis: an overview of vaccine adjuvants and their applications

S Ratnapriya, AA Sahasrabuddhe, A Dube - Vaccine, 2019 - Elsevier
Although there has been an extensive research on vaccine development over the last
decade and some vaccines have been commercialized for canine visceral leishmaniasis …