Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches
PD Noyes, KP Friedman, P Browne… - Environmental …, 2019 - ehp.niehs.nih.gov
Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …
Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption
AC Haigis, L Vergauwen, CA LaLone… - Toxicological …, 2023 - academic.oup.com
Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …
[HTML][HTML] Amphibian toxicity testing for identification of thyroid disrupting chemicals
ZC Dang - Environmental Pollution, 2022 - Elsevier
Both amphibian metamorphosis assay (AMA) and larval amphibian growth and
development assay (LAGDA) can detect thyroid-mediated modality and adversity on the …
development assay (LAGDA) can detect thyroid-mediated modality and adversity on the …
[HTML][HTML] High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition
J Wang, DR Hallinger, AS Murr, AR Buckalew… - Environment …, 2019 - Elsevier
In support of the Endocrine Disruptor Screening Program (EDSP), the US EPA's Office of
Research and Development (ORD) is developing high-throughput screening (HTS) …
Research and Development (ORD) is developing high-throughput screening (HTS) …
Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay
AR Buckalew, J Wang, AS Murr, C Deisenroth… - Archives of …, 2020 - Springer
The Fischer rat thyroid follicular cell line (FRTL-5) endogenously expresses the sodium-
iodide symporter (NIS) and has been used to identify environmental chemicals that perturb …
iodide symporter (NIS) and has been used to identify environmental chemicals that perturb …
In vitro screening for chemical inhibition of the iodide recycling enzyme, iodotyrosine deiodinase
JH Olker, JJ Korte, JS Denny, JT Haselman, PC Hartig… - Toxicology in Vitro, 2021 - Elsevier
The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied
molecular mechanism through which environmental chemicals can potentially cause thyroid …
molecular mechanism through which environmental chemicals can potentially cause thyroid …
[HTML][HTML] Endocrine disruption assessment in aquatic vertebrates–Identification of substance-induced thyroid-mediated effect patterns
L Lagadic, KK Coady, O Körner, TJ Miller… - Environment …, 2024 - Elsevier
Abstract According to the World Health Organisation and European Commission definitions,
substances shall be considered as having endocrine disrupting properties if they show …
substances shall be considered as having endocrine disrupting properties if they show …
Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models
S Couderq, M Leemans, JB Fini - Molecular and Cellular Endocrinology, 2020 - Elsevier
Thyroid hormones (THs) play critical roles in profound changes in many vertebrates, notably
in mammalian neurodevelopment, although the precise molecular mechanisms of these …
in mammalian neurodevelopment, although the precise molecular mechanisms of these …
Antioxidant gene signature impacts the immune infiltration and predicts the prognosis of kidney renal clear cell carcinoma
X Ren, L Ma, N Wang, R Zhou, J Wu, X Xie… - Frontiers in …, 2021 - frontiersin.org
Background: Oxidative stress is related to oncogenic transformation in kidney renal clear cell
carcinoma (KIRC). We intended to identify a prognostic antioxidant gene signature and …
carcinoma (KIRC). We intended to identify a prognostic antioxidant gene signature and …
Expanded high-throughput screening and chemotype-enrichment analysis of the phase II: e1k ToxCast library for human sodium-iodide symporter (NIS) inhibition
J Wang, AM Richard, AS Murr, AR Buckalew… - Archives of …, 2021 - Springer
The sodium-iodide symporter (NIS) mediates the uptake of iodide into the thyroid. Inhibition
of NIS function by xenobiotics has been demonstrated to suppress circulating thyroid …
of NIS function by xenobiotics has been demonstrated to suppress circulating thyroid …