Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …

The cellular uptake of free fatty acids (FFA) is followed by esterification to coenzyme A
(CoA), generating fatty acyl-CoAs that are substrates for oxidation or incorporation into …

Metabolic reprogramming plays an important role in supporting tumor growth. However, little
is known about the metabolic alterations that promote cancer metastasis. In this study, we …

Thioesterases are enzymes that hydrolyze thioester bonds in numerous biochemical
pathways, for example in fatty acid synthesis. This work reports known functions, structures …

Accumulating evidence indicates that acetate is increased under energy stress conditions
such as those that occur in diabetes mellitus and prolonged starvation. However, how and …

Thioesterases are present in all living cells and perform a wide range of important biological
functions by catalysing the cleavage of thioester bonds present in a diverse array of cellular …

Acyl‐coenzyme A thioesterase (Acot) enzymes are involved in a broad range of essential
intracellular roles including cell signalling, lipid metabolism, inflammation and the opening …

Lipid synthesis and transport are essential for energy, production of cell membrane, and cell
signaling. Acyl-CoA thioesterases (ACOTs) function to regulate intracellular levels of fatty …

Nonshivering thermogenesis occurs in brown adipose tissue to generate heat in response to
cold ambient temperatures. Thioesterase superfamily member 1 (Them1) is transcriptionally …

High levels of acetyl-CoA are considered a key metabolic feature of metastatic cancers.
However, the impacts of acetyl-CoA metabolic accumulation on cancer microenvironment …