Targeted drug delivery strategies for precision medicines
Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …
Precision medicine is propelled by technologies that enable molecular profiling, genomic …
Tumor abnormality-oriented nanomedicine design
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia
Bioinspired microrobots capable of actively moving in biological fluids have attracted
considerable attention for biomedical applications because of their unique dynamic features …
considerable attention for biomedical applications because of their unique dynamic features …
Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment
Immunosuppressive cells residing in the tumor microenvironment, especially tumor
associated macrophages (TAMs), hinder the infiltration and activation of T cells, limiting the …
associated macrophages (TAMs), hinder the infiltration and activation of T cells, limiting the …
Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets
The immunosuppressive microenvironment of solid tumours reduces the antitumour activity
of chimeric antigen receptor T cells (CAR-T cells). Here, we show that the release—through …
of chimeric antigen receptor T cells (CAR-T cells). Here, we show that the release—through …
Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines
C Gao, Q Huang, C Liu, CHT Kwong, L Yue… - Nature …, 2020 - nature.com
Vascular disease remains the leading cause of death and disability, the etiology of which
often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy …
often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy …
Massively evoking immunogenic cell death by focused mitochondrial oxidative stress using an AIE luminogen with a twisted molecular structure
Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer
immunotherapy. However, the currently available ICD inducers are still very limited and …
immunotherapy. However, the currently available ICD inducers are still very limited and …
In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles
The near-infrared-IIb (NIR-IIb)(1,500–1,700 nm) window is ideal for deep-tissue optical
imaging in mammals, but lacks bright and biocompatible probes. Here, we developed …
imaging in mammals, but lacks bright and biocompatible probes. Here, we developed …
Boosting checkpoint immunotherapy with biomaterials
The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …
In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma
C Gao, Q Wang, J Li, CHT Kwong, J Wei, B Xie… - Science …, 2022 - science.org
Cell-based drug carriers are mostly prepared in vitro, which may negatively affect the
physiological functions of cells, and induce possible immune rejections when applied to …
physiological functions of cells, and induce possible immune rejections when applied to …