The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in
chromosomal translocations in a subtype of acute leukemia, which represents approximately …

Infant B-cell acute lymphoblastic leukemia (B-ALL) accounts for 10% of childhood ALL. The
genetic hallmark of most infant B-ALL is chromosomal rearrangements of the mixed-lineage …

B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell
acute lymphoblastic leukemia remains fatal, especially in patients with t (4; 11), present in …

Chromosome translocations involving the mixed lineage leukemia (MLL) gene fuse it in
frame with multiple partner genes creating novel fusion proteins (MLL-FPs) that cause …

MLL fusion-driven activation of <italic>CDK6</italic> potentiates proliferation in <italic>MLL-</italic>
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Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires
Notch activation; however, most of the Notch-regulated elements controlling de novo HSC …

B cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. As
predicted by its prenatal origin, infant B-ALL (iB-ALL) shows an exceptionally silent DNA …

Due to the proliferation of genetic testing, pathogenic germline variants predisposing to
hereditary hematological malignancy syndrome (HHMS) have been identified in an …

Advances in treatment of childhood leukaemia has led to vastly improved survival rates,
however some subtypes such as those characterised by MLL gene rearrangement (MLL-r) …

Because of their immunomodulatory properties, human bone marrow stromal cells
(hBMSCs) represent promising stem cells for treatment of immune disorders. hBMSCs …