It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …

Companies have recently begun to sell a new service to patients considering in vitro
fertilization: embryo selection based on polygenic scores (ESPS). These scores represent …

The impact of genetic variation on overall disease burden has not been comprehensively
evaluated. We introduce an approach to estimate the effect of genetic risk factors on …

Preimplantation genetic testing (PGT) of in-vitro-fertilized embryos has been proposed as a
method to reduce transmission of common disease; however, more comprehensive embryo …

For decades, people have used genetic information to exercise control over the kinds of
children they will have. These technologies have largely targeted chromosomal and …

Preimplantation genetic testing using polygenic risk scores (PGT-P) has recently been
introduced. However, PGT-P has been met with many ethical concerns. It is therefore …

Numerous chronic diseases have a substantial hereditary component. Recent advances in
human genetics have allowed the extent of this to be quantified via genome-wide …

The recent introduction of polygenic risk scores within preimplantation genetic testing (PGT-
P) has been met with many concerns. To get more insights into the perspectives of relevant …

Importance Polygenic embryo screening (PES) is a novel technology that estimates the
likelihood of developing future conditions (eg, diabetes or depression) and traits (eg, height …