Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

Heparan sulfate proteoglycans (HSPGs) encompass a group of glycoproteins composed of
unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core …

Heparan sulfate proteoglycans (HSPGs) mediate essential interactions throughout the
extracellular matrix (ECM), providing signals that regulate cellular growth and development …

Heparan sulfate (HS) proteoglycans are extended (-GlcAβ1, 4GlcNAcα1, 4-) n co-polymers
containing decorations of sulfation and epimerization that are linked to cell surface and …

This chapter focuses on the structure, biosynthesis, and general biology of proteoglycans.
Topics include a description of the major families of proteoglycans, their characteristic …

Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …

Heparan sulfates are complex polysaccharides that mediate the interaction with a broad
range of protein ligands at the cell surface. A key step in heparan sulfate biosynthesis is …

Cell surface proteoglycans are known to be important regulators of many aspects of cell
behavior. The principal family of transmembrane proteoglycans is the syndecans, of which …

Heparan sulfate (HS) polysaccharides are major constituents of the extracellular matrix,
which are involved in myriad structural and signaling processes. Mature HS polysaccharides …

Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …