The decisive early phase of bone regeneration

GN Duda, S Geissler, S Checa, S Tsitsilonis… - Nature Reviews …, 2023 - nature.com
Bone has a remarkable endogenous regenerative capacity that enables scarless healing
and restoration of its prior mechanical function, even under challenging conditions such as …

Unraveling the mechanobiology of extracellular matrix

V Vogel - Annual review of physiology, 2018 - annualreviews.org
Cells need to be anchored to extracellular matrix (ECM) to survive, yet the role of ECM in
guiding developmental processes, tissue homeostasis, and aging has long been …

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix

KE Kubow, R Vukmirovic, L Zhe, E Klotzsch… - Nature …, 2015 - nature.com
Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and
diseased tissues—particularly in development, wound healing, tissue regeneration and …

Application of FRET biosensors in mechanobiology and mechanopharmacological screening

L Liu, F He, Y Yu, Y Wang - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Extensive studies have shown that cells can sense and modulate the biomechanical
properties of the ECM within their resident microenvironment. Thus, targeting the …

Review on cell mechanics: experimental and modeling approaches

ML Rodriguez, PJ McGarry… - Applied …, 2013 - asmedigitalcollection.asme.org
The interplay between the mechanical properties of cells and the forces that they produce
internally or that are externally applied to them play an important role in maintaining the …

Microfluidic 3D models of cancer

KE Sung, DJ Beebe - Advanced drug delivery reviews, 2014 - Elsevier
Despite advances in medicine and biomedical sciences, cancer still remains a major health
issue. Complex interactions between tumors and their microenvironment contribute to tumor …

Mechanochemistry of collagen

SM Siadat, JW Ruberti - Acta Biomaterialia, 2023 - Elsevier
The collagen molecular family is the result of nearly one billion years of evolution. It is a
unique family of proteins, the majority of which provide general mechanical support to …

Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts

P Kollmannsberger, CM Bidan, JWC Dunlop… - Science …, 2018 - science.org
Myofibroblasts orchestrate wound healing processes, and if they remain activated, they drive
disease progression such as fibrosis and cancer. Besides growth factor signaling, the local …

Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization

D Chen, LR Smith, G Khandekar, P Patel, CK Yu… - Scientific reports, 2020 - nature.com
The extracellular matrix (ECM) is a complex mixture composed of fibrillar collagens as well
as additional protein and carbohydrate components. Proteoglycans (PGs) contribute to the …

Cellular forces and matrix assembly coordinate fibrous tissue repair

MS Sakar, J Eyckmans, R Pieters, D Eberli… - Nature …, 2016 - nature.com
Planar in vitro models have been invaluable tools to identify the mechanical basis of wound
closure. Although these models may recapitulate closure dynamics of epithelial cell sheets …