The decisive early phase of bone regeneration
Bone has a remarkable endogenous regenerative capacity that enables scarless healing
and restoration of its prior mechanical function, even under challenging conditions such as …
and restoration of its prior mechanical function, even under challenging conditions such as …
Unraveling the mechanobiology of extracellular matrix
V Vogel - Annual review of physiology, 2018 - annualreviews.org
Cells need to be anchored to extracellular matrix (ECM) to survive, yet the role of ECM in
guiding developmental processes, tissue homeostasis, and aging has long been …
guiding developmental processes, tissue homeostasis, and aging has long been …
Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix
KE Kubow, R Vukmirovic, L Zhe, E Klotzsch… - Nature …, 2015 - nature.com
Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and
diseased tissues—particularly in development, wound healing, tissue regeneration and …
diseased tissues—particularly in development, wound healing, tissue regeneration and …
Application of FRET biosensors in mechanobiology and mechanopharmacological screening
Extensive studies have shown that cells can sense and modulate the biomechanical
properties of the ECM within their resident microenvironment. Thus, targeting the …
properties of the ECM within their resident microenvironment. Thus, targeting the …
Review on cell mechanics: experimental and modeling approaches
ML Rodriguez, PJ McGarry… - Applied …, 2013 - asmedigitalcollection.asme.org
The interplay between the mechanical properties of cells and the forces that they produce
internally or that are externally applied to them play an important role in maintaining the …
internally or that are externally applied to them play an important role in maintaining the …
Microfluidic 3D models of cancer
Despite advances in medicine and biomedical sciences, cancer still remains a major health
issue. Complex interactions between tumors and their microenvironment contribute to tumor …
issue. Complex interactions between tumors and their microenvironment contribute to tumor …
Mechanochemistry of collagen
SM Siadat, JW Ruberti - Acta Biomaterialia, 2023 - Elsevier
The collagen molecular family is the result of nearly one billion years of evolution. It is a
unique family of proteins, the majority of which provide general mechanical support to …
unique family of proteins, the majority of which provide general mechanical support to …
Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts
Myofibroblasts orchestrate wound healing processes, and if they remain activated, they drive
disease progression such as fibrosis and cancer. Besides growth factor signaling, the local …
disease progression such as fibrosis and cancer. Besides growth factor signaling, the local …
Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization
The extracellular matrix (ECM) is a complex mixture composed of fibrillar collagens as well
as additional protein and carbohydrate components. Proteoglycans (PGs) contribute to the …
as additional protein and carbohydrate components. Proteoglycans (PGs) contribute to the …
Cellular forces and matrix assembly coordinate fibrous tissue repair
Planar in vitro models have been invaluable tools to identify the mechanical basis of wound
closure. Although these models may recapitulate closure dynamics of epithelial cell sheets …
closure. Although these models may recapitulate closure dynamics of epithelial cell sheets …