Structural and functional collapse of the balance between excitatory (E) and inhibitory (I)
synapses, ie, synaptic E/I balance, underlies the pathogeneses of various central nervous …

Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

Epilepsy is a chronic disorder characterized by spontaneous recurrent seizures. Brain
inflammation is increasingly recognized as a critical factor for seizure precipitation, but the …

In the healthy brain, neuronal excitability and synaptic strength are homeostatically
regulated to keep neuronal network activity within physiological boundaries. Epilepsy is …

A deeper understanding of post-stroke plasticity is critical to devise more effective
pharmacological and rehabilitative treatments. The GABAergic system is one of the key …

Impairments of the dialog between excitation and inhibition (E/I) is commonly associated to
neuropsychiatric disorders like autism, bipolar disorders and epilepsy. Moderate levels of …

Purpose Limited restoration of function is known to occur spontaneously after an ischemic
injury to the primary motor cortex. Evidence suggests that Pre-Motor Areas (PMAs) may “take …

The process through which neurons are labeled is a key methodological choice in
measuring neuron morphology. However little is known about how this choice may bias …

Background Glioblastomas are the most aggressive type of brain tumor. A successful
treatment should aim at halting tumor growth and protecting neuronal cells to prevent …

Neuronal hyperexcitability often results from an unbalance between excitatory and inhibitory
neurotransmission, but the synaptic alterations leading to enhanced seizure propensity are …