Codrug or mutual prodrug is an approach where various effective drugs, which are
associated with some drawbacks, can be modified by attaching with other drugs of same or …

Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic
inflammatory diseases suffer from several undesired side effects, the most important being …

A therapeutically significant drug may have limited utilization in clinical practice because of
poor organoleptic properties, poor bioavailability, short duration of action, nonspecificity …

Inflammation mediators, prostaglandins are causing inflammation, pain and pyrexia in the
body. Synthesis of these mediators can be effectively blocked by administering the non …

Results: As an outcome the search for a prodrug or mutual prodrug with reduced toxicity has
continued during recent years. This present review emphasizes the common help to revamp …

A drug is a chemical substance which possesses medicinal properties and exerts
pharmacological action upon administration into the body. When a drug gets metabolized …

Many currently available drugs show unfavourable physicochemical properties for delivery
into or across the skin and temporary chemical modulation of the penetrant is one option to …

The purpose of this study was to investigate the possibility of parenteral delivery of poorly
water-soluble lipophilic drugs using a phospholipid-based microemulsion system. Ibuprofen …

Gastric irritation and ulcerogenic effect of the acidic NSAIDs are of the most challenging
problems in designing novel anti-inflammatory agents. In this study, the new prodrugs were …

The discovery of the inducible isoform of cyclooxygenase enzyme (COX-2) spurred the
search for anti-inflammatory agents devoid of the undesirable effects associated with …