Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Food is a potent natural reward and food intake is a complex process. Reward and
gratification associated with food consumption leads to dopamine (DA) production, which in …

Signals of energy homeostasis interact closely with neural circuits of motivation to control
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …

This manuscript summarizes the proceedings of the symposium entitled,“Stress, Palatable
Food and Reward”, that was chaired by Drs. Linda Rinaman and Yvonne Ulrich-Lai at the …

BACKGROUND: The biological mechanisms that link the development of depression to
metabolic disorders such as obesity and diabetes remain obscure. Dopamine-and plasticity …

Obesity markedly increases the odds of developing depression. Depressed mood not only
impairs motivation, quality of life and overall functioning but also increases the risks of …

The glucagon-like peptide 1 (GLP-1) system is a recently established target for type 2
diabetes treatment. In addition to regulating glucose homeostasis, GLP-1 also reduces food …

Metabolic disorders have seen an increased prevalence in recent years in developed as
well as developing countries. While it is clear lifestyle choices and habits have contributed to …

Running wheels are commonly employed to measure rodent physical activity in a variety of
contexts, including studies of energy balance and obesity. There is no consensus on the …