Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially life-
threatening monogenic disorder in humans, characterized by progressive development and …

Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common
inherited disorder causing kidney disease. Current clinical management of ADPKD focuses …

Background In autosomal dominant polycystic kidney disease (ADPKD), total kidney volume
(TKV) is regarded as an important biomarker of disease progression and different methods …

Although translational research into autosomal dominant polycystic kidney disease
(ADPKD) and its pathogenesis has made considerable progress, there is presently lack of …

Autosomal dominant polycystic kidney disease (ADPKD) can be caused by mutations in the
PKD1 or PKD2 genes. The PKD1 gene product is a Wnt cell-surface receptor. We previously …

Polycystic kidney disease (PKD) is one of the most common life-threatening genetic
diseases. Jared J. Grantham, MD, has done more than any other individual to promote PKD …

Polycystic kidney disease (PKD) results in the formation of renal cysts that can impair
function leading to renal failure. DNA damage accumulates in renal epithelial cells in PKD …

Introduction Autosomal dominant polycystic kidney disease (ADPKD) is a progressive
genetic kidney disease. Studies of ADPKD presented results using different outcome …

The classic role of the Na-K-ATPase is that of a primary active transporter that utilizes cell
energy to establish and maintain transmembrane Na+ and K+ gradients to preserve cell …

Progression of cystic kidney disease has been linked to activation of the mTORC1 signaling
pathway. Yet the utility of mTORC1 inhibitors to treat patients with polycystic kidney disease …