During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

CRISPR-Cas9 technology provides a powerful system for genome engineering. However,
variable activity across different single guide RNAs (sgRNAs) remains a significant …

Early embryonic development is driven exclusively by maternal gene products deposited
into the oocyte. Although critical in establishing early developmental programs, maternal …

Critical swimming speed (Ucrit) is a standard measurement to assess swimming capabilities
of fishes. To conduct this measurement a fish is introduced into a water tunnel in which the …

The process of gastrulation is a pivotal step in the formation of the vertebrate body plan. The
primary function of gastrulation is the correct placement of precursor tissues for subsequent …

The segment polarity gene hedgehog (hh) encodes a novel signaling protein that mediates
local cell-cell interactions in the developing Drosophila embryo. Here we describe the …

Mesoderm formation is critical for the establishment of the animal body plan and in
Drosophila requires the snail gene. This report concerns the cloning and expression pattern …

Summary HNF-3/?, a member of the HNF4/fork head family of transcription factors, is
expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of …

Studying the formation of the embryonic axes in mammals poses a special problem because
patterning of the embryo itself is a relatively late event in development. In the mouse, explicit …