The circadian immune system

C Wang, LK Lutes, C Barnoud, C Scheiermann - Science immunology, 2022 - science.org
The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

Drivers of infectious disease seasonality: potential implications for COVID-19

N Kronfeld-Schor, TJ Stevenson… - Journal of biological …, 2021 - journals.sagepub.com
Not 1 year has passed since the emergence of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19) …

Influence of circadian clocks on adaptive immunity and vaccination responses

LM Ince, C Barnoud, LK Lutes, R Pick, C Wang… - Nature …, 2023 - nature.com
The adaptive immune response is under circadian control, yet, why adaptive immune
reactions continue to exhibit circadian changes over long periods of time is unknown. Using …

Determinants of antibody responses to SARS-CoV-2 vaccines: population-based longitudinal study (COVIDENCE UK)

DA Jolliffe, SE Faustini, H Holt, N Perdek, S Maltby… - Vaccines, 2022 - mdpi.com
Antibody responses to SARS-CoV-2 vaccines vary for reasons that remain poorly
understood. A range of sociodemographic, behavioural, clinical, pharmacologic and …

Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of health care workers

W Wang, P Balfe, DW Eyre, SF Lumley… - Journal of biological …, 2022 - journals.sagepub.com
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is a global crisis with unprecedented challenges for public health …

Circadian immunity from bench to bedside: a practical guide

H Mok, E Ostendorf, A Ganninger… - The Journal of …, 2024 - Am Soc Clin Investig
The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …

White blood cells in pregnancy: reference intervals for before and after delivery

S Dockree, B Shine, S Pavord, L Impey, M Vatish - EBioMedicine, 2021 - thelancet.com
Background White blood cells (WBC) are commonly measured to investigate suspected
infection and inflammation in pregnant women, but the pregnancy-specific reference interval …

Circadian Rhythms in Anticancer Immunity: Mechanisms and Treatment Opportunities

R Pick, C Wang, Q Zeng, ZM Gül… - Annual Review of …, 2024 - annualreviews.org
Circadian rhythms of approximately 24 h have emerged as important modulators of the
immune system. These oscillations are important for mounting short-term, innate immune …

The contribution of sleep to the neuroendocrine regulation of rhythms in human leukocyte traffic

T Lange, F Luebber, H Grasshoff… - Seminars in …, 2022 - Springer
Twenty-four-hour rhythms in immune parameters and functions are robustly observed
phenomena in biomedicine. Here, we summarize the important role of sleep and associated …

Is elevated neutrophil count and neutrophil-to-lymphocyte ratio a cause or consequence of schizophrenia?—a scoping review

AA Sandberg, VM Steen, A Torsvik - Frontiers in Psychiatry, 2021 - frontiersin.org
Background: Several studies have found an association between elevated neutrophil count
or neutrophil-to-lymphocyte ratio (NLR) in peripheral blood from patients with schizophrenia …