The exposure of hepatocytes to high concentrations of lipids and carbohydrates and the
ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A …

Obesity has been described as a global epidemic and is a low-grade chronic inflammatory
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …

The intestinal microbiota is known to regulate host energy homeostasis and can be
influenced by high-calorie diets. However, changes affecting the ecosystem at the functional …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, placing an increasing burden on human health. NAFLD is a complex …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging
from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly …

Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic disorder related to
type 2 diabetes (T2D). The disease can evolve toward nonalcoholic steatohepatitis (NASH) …

Dietary ratios of n-3/n-6 polyunsaturated fatty acids (PUFAs) have been implicated in
controlling markers of metabolic disorders, including obesity, insulin resistance (IR) …

Aims/hypotheses Ceramides and other sphingolipids comprise a family of lipid molecules
that accumulate in skeletal muscle and promote insulin resistance. Chronic endurance …

Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of health
problems in Western (industrialized) countries. Moreover, the incidence of infantile NAFLD is …