Background The collective of somatic mutations in a genome represents a record of
mutational processes that have been operative in a cell. These processes can be …

Colorectal malignancies are a leading cause of cancer-related death and have undergone
extensive genomic study,. However, DNA mutations alone do not fully explain malignant …

Epidemiological studies have identified many environmental agents that appear to
significantly increase cancer risk in human populations. By analyzing tumor genomes from …

Mutational signatures refer to patterns in the occurrence of somatic mutations that might be
uniquely ascribed to particular mutational process. Tumour mutation catalogues can reveal …

Mutations are the driving force of evolution, yet they underlie many diseases, in particular,
cancer. They are thought to arise from a combination of stochastic errors in DNA processing …

The dominant mutational signature in colorectal cancer genomes is C> T deamination
(COSMIC Signature 1) and, in a small subgroup, mismatch repair signature (COSMIC …

To dissect the mechanisms underlying the inflation of variants in the Severe Acute
Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) genome, we present a large-scale …

Genome sequencing can be used to detect DNA repair failures in tumors and learn about
underlying mechanisms. Here, we synthesize findings from genomic studies that examined …

To provide precision medicine for better cancer care, researchers must work on clinical
patient data, such as electronic medical records, physiological measurements, biochemistry …

Background Germline mutations in the BRCA1 and BRCA2 genes predispose carriers to
breast and ovarian cancer, and there remains a need to identify the specific genomic …