The bottom-up construction of a living cell using non-living materials represents a grand
challenge in science and technology. Reproduction of cells into similar offspring is key to …

Life-like systems need to maintain a basal metabolism, which includes importing a variety of
building blocks required for macromolecule synthesis, exporting dead-end products, and …

The ability of living organisms to perform structure, energy, and information‐related
processes for molecular self‐assembly through compartmentalization and chemical …

The bottom-up construction of an autonomously growing, self-reproducing cell represents a
great challenge for synthetic biology. Synthetic cellular systems are envisioned as out-of …

Artificial cells that mimic the architectural and functional characteristics of living cells not only
shed light on the physical principle of life but also facilitate development in the areas such as …

Connecting molecular interactions to emergent properties is a goal of physical chemistry,
self-assembly, and soft matter science. We show that for fatty acid bilayers, vesicle rupture …

Excitement about synthetic biology is higher than ever, and the fabrication of synthetic cells
and tissues of significant complexity continues to be a central goal. While the definition of …

The research described in this thesis focuses on the construction of synthetic cells from the
bottom-up, ie, by assembling non-living components to mimic aspects of living cells and …

Synthetic cells are envisioned as autonomous systems that maintain a basal metabolism
and are able to self-replicate by growth and division. Building these life-like mimics from the …