Nanomaterial-based bioorthogonal nanozymes for biological applications

S Fedeli, J Im, S Gopalakrishnan, JL Elia… - Chemical Society …, 2021 - pubs.rsc.org
Bioorthogonal transformations are chemical reactions that use pathways which biological
processes do not access. Bioorthogonal chemistry provides new approaches for imaging …

Inorganic nanoparticles as scaffolds for bioorthogonal catalysts

CM Hirschbiegel, X Zhang, R Huang, YA Cicek… - Advanced drug delivery …, 2023 - Elsevier
Bioorthogonal transition metal catalysts (TMCs) transform therapeutically inactive molecules
(pro-drugs) into active drug compounds. Inorganic nanoscaffolds protect and solubilize …

Degradable ZnS-supported bioorthogonal nanozymes with enhanced catalytic activity for intracellular activation of therapeutics

X Zhang, S Lin, R Huang, A Gupta… - Journal of the …, 2022 - ACS Publications
Bioorthogonal catalysis using transition-metal catalysts (TMCs) provides a toolkit for the in
situ generation of imaging and therapeutic agents in biological environments. Integrating …

In situ activation of therapeutics through bioorthogonal catalysis

W Wang, X Zhang, R Huang, CM Hirschbiegel… - Advanced drug delivery …, 2021 - Elsevier
Bioorthogonal chemistry refers to any chemical reactions that can occur inside of living
systems without interfering with native biochemical processes, which has become a …

Advances in organometallic/organic nanozymes and their applications

X Zhang, S Lin, S Liu, X Tan, Y Dai, F Xia - Coordination Chemistry …, 2021 - Elsevier
Nanozymes, the next-generation artificial enzymes, are nanomaterials with enzyme-like
characteristics and have been widely used in detection, disease diagnosis, biological …

Bioorthogonal nanozymes for breast cancer imaging and therapy

X Zhang, Y Liu, J Doungchawee… - Journal of Controlled …, 2023 - Elsevier
Bioorthogonal catalysis via transition metal catalysts (TMCs) enables the generation of
therapeutics locally through chemical reactions not accessible by biological systems. This …

Biomimetic and bioorthogonal nanozymes for biomedical applications

C Keum, CM Hirschbiegel, S Chakraborty, S Jin… - Nano …, 2023 - Springer
Nanozymes mimic the function of enzymes, which drive essential intracellular chemical
reactions that govern biological processes. They efficiently generate or degrade specific …

Macrophage-encapsulated bioorthogonal nanozymes for targeting cancer cells

R Das, J Hardie, BP Joshi, X Zhang, A Gupta… - JACS Au, 2022 - ACS Publications
Macrophages migrate to tumor sites by following chemoattractant gradients secreted by
tumor cells, providing a truly active targeting strategy for cancer therapy. However …

Transition metal‐promoted reactions in aqueous media and biological settings

P Destito, C Vidal, F López… - Chemistry–A European …, 2021 - Wiley Online Library
During the last decade, there has been a tremendous interest for developing non‐natural
biocompatible transformations in biologically relevant media. Among the different …

Biodegradable nanoemulsion-based bioorthogonal nanocatalysts for intracellular generation of anticancer therapeutics

A Nabawy, A Gupta, M Jiang, CM Hirschbiegel… - Nanoscale, 2023 - pubs.rsc.org
Bioorthogonal catalysis mediated by transition metal catalysts (TMCs) provides controlled in
situ activation of prodrugs through chemical reactions that do not interfere with cellular …