Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes | Chemical Reviews ACS
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Chiral ligands play a central role in enantioselective transition-metal catalysis. The success
of achiral N-heterocyclic carbenes (NHCs) as stable electron-rich neutral ligands in …

Conjugate addition is among the most important synthetic protocols for constructing carbon
skeletons and is widely used to synthesize natural products and drugs. However …

N-Heterocyclic carbenes (NHCs) are cyclic carbenes bearing at least one R-amino
substituent. 1 The most common subclasses of NHCs are represented in Chart 1. Early work …

N-Heterocyclic carbenes (NHCs) are defined as singlet carbenes, in which the divalent
carbenic center is connected directly to at least one nitrogen atom within the heterocycle. 1 …

An N-heterocyclic carbene (NHC) contains a carbene carbon incorporated in a nitrogen-
containing heterocycle, presumably reactive and difficult to isolate. 1 The first isolation of …

Ligand design has met with considerable success with both categories of hybrid ligands,
which are characterized by chemically different donor groups, and of N-heterocyclic …

We provide an overview on the state‐of‐the‐art in transition‐metal complexes formed with
water‐soluble NHC ligands. Paths to introducing water solubility by ligand design are …

The strong σ-donor but poor π-acceptor abilities of N-heterocyclic carbenes (NHCs) result in
chemical stability and coordination versatility, thus allowing them to coordinate with many …

All-carbon quaternary stereocenters are ubiquitous motifs in biological products and
pharmaceutical agents. However, due to sterical reasons, these centers are not always …