Despite the novel diagnostic methods and therapies implemented in oncology, the number
of patients that succumb by the cancer remains high globally. Currently studies point out that …

Most human invasive breast cancers (IBCs) appear to develop over long periods of time
from certain pre-existing benign lesions. Of the many types of benign lesions in the human …

Abstract The 55-kilodalton (kDa) protein from the E1B-region of adenovirus binds to and
inactivates the p53 gene, which is mutated in half of human cancers. We have previously …

Abstract ONYX-015 is an E1B-55kDa gene-deleted adenovirus engineered to selectively
replicate in and lyse p53-deficient cancer cells. To evaluate the selectivity of ONYX-015 …

The first reports suggesting an involvement of human papillomavirus (HPV) in the
development of both benign and malignant squamous cell tumours of the oesophagus date …

To determine whether cancer patients with tumor suppressor gene abnormality survive for a
shorter time when their growth was stimulated by growth factors, we examined 290 non …

Novel therapies are needed for locally advanced pancreatic carcinoma. ONYX-015 (dl1520)
is an E1B-55 kDa region-deleted adenovirus that selectively replicates in and lyses tumor …

Mutations in the essential tumor suppressor gene, TP53, are observed in only 5–10% of
acute myeloid leukemia (AML) cases, but are highly associated with therapy-related AML …

Epithelial dysplasia is usually used to establish the prognosis of oral premalignant lesions.
Its assessment, however, is subjective and does not always correctly predict the outcome of …

In the last decades, a group of viruses has received great attention due to its relationship
with cancer development and its wide distribution throughout the vertebrates: the …