The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

ABSTRACT A refined understanding of the role of complement in the pathogenesis of
glomerular and other kidney diseases has, over the past two decades, been matched by the …

Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenia purpura (TTP) are rare
diseases sharing a common pathological feature, thrombotic microangiopathy (TMA). TMA is …

Combination therapy with glucocorticoids, cyclophosphamide, and plasmapheresis is
recommended as the standard treatment for anti-glomerular basement membrane (anti …

Thrombocytopenia frequently occurs in patients with sepsis. Disseminated intravascular
coagulation (DIC) may be a possible cause of thrombocytopenia owing to its high …

Introduction Comprehensive information about atypical hemolytic uremic syndrome (aHUS)
is relatively scarce outside of Europe and North America. This narrative review assembles …

What is known and objective: The C5 inhibitor eculizumab is the standard of care for
treatment of atypical haemolytic uraemic syndrome (aHUS). Ravulizumab, a next …

RATIONALE Down syndrome (DS) is a congenital condition highly associated with
obstructive sleep apnea (OSA), a complex disorder with significant clinical consequences …

Postsurgical thrombotic microangiopathy (TMA) is a complication associated with significant
morbidity and mortality. Still, the pathophysiological underlying mechanism of postsurgical …

Atypical hemolytic uremic syndrome (aHUS) is a type of thrombotic microangiopathy and is
characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney …