[HTML][HTML] Comprehensive review on Alzheimer's disease: causes and treatment

Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) is a disorder that causes degeneration of the cells in the brain and
it is the main cause of dementia, which is characterized by a decline in thinking and …

Biosensing based on field-effect transistors (FET): Recent progress and challenges

D Sadighbayan, M Hasanzadeh… - TrAC Trends in Analytical …, 2020 - Elsevier
The use of field-Effect-Transistor (FET) type biosensing arrangements has been highlighted
by researchers in the field of early biomarker detection and drug screening. Their non …

[HTML][HTML] Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update

LK Huang, YC Kuan, HW Lin, CJ Hu - Journal of Biomedical Science, 2023 - Springer
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet
medical need worldwide. The pathogenesis of AD involves various pathophysiological …

[HTML][HTML] Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases

SW Bothwell, D Janigro, A Patabendige - Fluids and Barriers of the CNS, 2019 - Springer
The fine balance between the secretion, composition, volume and turnover of cerebrospinal
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …

[HTML][HTML] Wnt signaling deregulation in the aging and Alzheimer's brain

E Palomer, J Buechler, PC Salinas - Frontiers in cellular …, 2019 - frontiersin.org
Growing evidence suggests that synaptic signaling is compromised in the aging brain and in
Alzheimer's disease (AD), contributing to synaptic decline. Wnt signaling is a prominent …

[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives

KD Fasae, AO Abolaji, TR Faloye, AY Odunsi… - Journal of Trace …, 2021 - Elsevier
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …

Clinical aspects of Alzheimer's disease

M Zvěřová - Clinical biochemistry, 2019 - Elsevier
Alzheimer's disease is a progressive, irreversible, incurable, neurodegenerative illness and
the most common of the dementing disorders. It starts usually after 60 years of age and may …

Natural products and their bioactive compounds: neuroprotective potentials against neurodegenerative diseases

NS Mohd Sairazi… - … Based Complementary and …, 2020 - Wiley Online Library
In recent years, natural products, which originate from plants, animals, and fungi, together
with their bioactive compounds have been intensively explored and studied for their …

Computational modeling of dementia prediction using deep neural network: analysis on OASIS dataset

S Basheer, S Bhatia, SB Sakri - IEEE access, 2021 - ieeexplore.ieee.org
Alzheimer is a progressive disease and it is the most prevalent neurodegenerative disorder.
It is believed that the people with mild cognitive impairment are at high risk of developing …

[HTML][HTML] Exploring the pathogenesis of Alzheimer disease in basal forebrain cholinergic neurons: converging insights from alternative hypotheses

XQ Chen, WC Mobley - Frontiers in neuroscience, 2019 - frontiersin.org
Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens (Apostolova …