Mechanistic pathways of sex differences in cardiovascular disease

V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2016 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

[HTML][HTML] The relationship between circulating testosterone and inflammatory cytokines in men

NV Mohamad, SK Wong, WNW Hasan, JJ Jolly… - The Aging …, 2019 - Taylor & Francis
Testosterone is the predominant gonadal androgen in men. Low testosterone levels are
found to be associated with an increased in metabolic risk and systematic inflammation …

Sex differences in autoimmune disease from a pathological perspective

DL Fairweather, S Frisancho-Kiss, NR Rose - The American journal of …, 2008 - Elsevier
Autoimmune diseases affect∼ 8% of the population, 78% of whom are women. The reason
for the high prevalence in women is unclear. Women are known to respond to infection …

[HTML][HTML] Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with …

R Zhou, X Yang, X Li, Y Qu, Q Huang, X Sun… - Journal of …, 2019 - Springer
Background Sepsis is a critical disease associated with extremely high mortality. Some
severe forms of sepsis can induce brain injury, thus causing behavioral and cognitive …

Preconditioning mesenchymal stem cells with transforming growth factor-alpha improves mesenchymal stem cell-mediated cardioprotection

JL Herrmann, Y Wang, AM Abarbanell, BR Weil, J Tan… - Shock, 2010 - journals.lww.com
Mesenchymal stem cells (MSCs) are a promising therapy for acute organ ischemia in part
due to their paracrine production of growth factors. However, transplanted cells encounter …

The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process

TH Jones, F Saad - Atherosclerosis, 2009 - Elsevier
It is becoming increasingly evident that the low serum levels of testosterone experienced by
aging men are associated with increased all-cause mortality from CHD and other vascular …

Sex‐specific and hormone‐related differences in vascular remodelling in atherosclerosis

A Yerly, EPC van der Vorst… - European Journal of …, 2023 - Wiley Online Library
Atherosclerosis, a lipid‐driven inflammatory disease, is the main underlying cause of
cardiovascular diseases (CVDs) both in men and women. Sex‐related dimorphisms …

Testosterone and the cardiovascular system: a comprehensive review of the basic science literature

MJ Herring, PM Oskui, SL Hale… - Journal of the American …, 2013 - Am Heart Assoc
An increasing number of elderly men are receiving exogenous testosterone to treat
hypogonadism, low libido, and general weakness. 1 The impact of testosterone on the …

[HTML][HTML] Dexmedetomidine prevents septic myocardial dysfunction in rats via activation of α7nAChR and PI3K/Akt-mediated autophagy

T Yu, D Liu, M Gao, P Yang, M Zhang, F Song… - Biomedicine & …, 2019 - Elsevier
Abstract Background and purpose Dexmedetomidine (Dex) has been shown to elicit cardio-
protective effects in sepsis. The aim of this study was to investigate the role of autophagy in …

[HTML][HTML] Sex differences in therapies against myocardial ischemia-reperfusion injury: from basic science to clinical perspectives

L Medzikovic, T Azem, W Sun, P Rejali, L Esdin… - Cells, 2023 - mdpi.com
Mortality from myocardial infarction (MI) has declined over recent decades, which could be
attributed in large part to improved treatment methods. Early reperfusion is the cornerstone …