In humans, cell fusion is restricted to only a few cell types under normal conditions. In the
placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant …

Kruppel-like factors (KLFs) are a family of zinc finger transcription factors that have been
found to play an essential role in the development of various human tissues, including …

The placenta becomes one of the most diversified organs during placental mammal
radiation. The main in vitro model for studying mouse trophoblast development is the 2D …

Trophoblast cell differentiation is of paramount importance for successful pregnancy.
Krüppel‐like factor 6 (KLF6), a transcription factor with diverse roles in cell physiology and …

Abstract The Galectin-Related Protein (GRP), encoded by the LGALSL gene, assigned to
the protein family of β-galactoside-binding Galectins, has lost carbohydrate-binding abilities …

Fetal growth restriction (FGR) is a relatively common complication of pregnancy, and
insufficient syncytialization in the placenta may play an important role in the pathogenesis of …

Preeclampsia (PE) occurs in 5% to 7% of all pregnancies, and the PE that results from
abnormal placentation acts as a primary cause of maternal and neonatal morbidity and …

Introduction HIF-1α, the master regulator of hypoxia cellular response, is stabilized under
low oxygen levels and degraded in the presence of oxygen but its transcription, translation …

Introduction Trophoblast homeostasis and differentiation require a proper endoplasmic
reticulum (ER) function. The Krüppel-like factor-6 (KLF6) transcription factor modulates …

Introduction Placental extravillous trophoblasts play a crucial role in the establishment of a
healthy pregnancy. Reactive oxygen species (ROS) may contribute to their differentiation …