Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

Parkinson's disease, like many common age-related conditions, is now recognized to have a
substantial genetic component. Here, I discuss how mutations in a large complex gene …

Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2)
protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and
sporadic Parkinson's disease (PD). Elevated LRRK2 kinase activity and neurodegeneration …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease
(PD), but the underlying pathophysiological mechanisms and the normal function of this …

Genetic studies have provided valuable insight into the pathological mechanisms underlying
Parkinson's disease (PD). The elucidation of genetic components to what was once largely …

Mutations in the leucine‐rich repeat kinase 2 (LRRK 2)‐encoding gene are the most
common cause of monogenic Parkinson's disease. The identification of LRRK 2 …

The study of rare, inherited mutations underlying familial forms of Parkinson's disease has
provided insight into the molecular mechanisms of disease pathogenesis. Mutations in these …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) have been associated with familial
and sporadic cases of Parkinson disease. Mutant LRRK2 causes in vitro and in vivo neurite …

Abstract Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most important genetic
contributors to Parkinson's disease. LRRK2 has been implicated in a number of cellular …