Heart disease and stroke statistics—2022 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, A Alonso… - Circulation, 2022 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Heart disease and stroke statistics—2023 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2023 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

[HTML][HTML] Heart disease and stroke statistics-2021 update: a report from the American Heart Association.

SS Virani, A Alonso, HJ Aparicio, EJ Benjamin… - 2021 - dukespace.lib.duke.edu
Background The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Molecular genetic framework underlying pulmonary arterial hypertension

L Southgate, RD Machado, S Gräf… - Nature Reviews …, 2020 - nature.com
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder typified by occlusion
of the pulmonary arterioles owing to endothelial dysfunction and uncontrolled proliferation of …

[HTML][HTML] Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity

O Bondareva, JR Rodríguez-Aguilera, F Oliveira… - Nature …, 2022 - nature.com
Obesity promotes diverse pathologies, including atherosclerosis and dementia, which
frequently involve vascular defects and endothelial cell (EC) dysfunction. Each organ has …

[HTML][HTML] The 6th World Symposium on Pulmonary Hypertension: what's old is new

DF Condon, NP Nickel, R Anderson, S Mirza… - …, 2019 - ncbi.nlm.nih.gov
Abstract In February 2018, the 6th World Symposium on Pulmonary Hypertension (WSPH)
brought together experts from various disciplines to review the most relevant clinical and …

Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension

F Potus, MW Pauciulo, EK Cook, N Zhu, A Hsieh… - Circulation, 2020 - Am Heart Assoc
Background: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy. Hereditary
cases are associated with germline mutations in BMPR2 and 16 other genes; however …

Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling

A Balistrieri, A Makino, JXJ Yuan - Physiological Reviews, 2023 - journals.physiology.org
The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

[HTML][HTML] Sex, gender, and sex hormones in pulmonary hypertension and right ventricular failure

J Hester, C Ventetuolo, T Lahm - Comprehensive Physiology, 2019 - ncbi.nlm.nih.gov
Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension

J Rodor, SH Chen, JP Scanlon… - Cardiovascular …, 2022 - academic.oup.com
Aims Endothelial cell (EC) dysfunction drives the initiation and pathogenesis of pulmonary
arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell …