The PCR technique has been known to the general public since the pandemic outbreak of
COVID-19. This technique has progressed through three stages: from simple PCR to real …

Human T cells have a diverse T‐cell receptor (TCR) repertoire that endows them with the
ability to identify and defend against a broad spectrum of antigens. The universe of possible …

Antigen discovery technologies have largely focused on major histocompatibility complex
(MHC) class I-restricted human T cell receptors (TCRs), leaving methods for MHC class II …

Simultaneous delivery of mRNA to multiple populations of antigen (Ag)–specific CD8+ T
cells is challenging given the diversity of peptide epitopes and polymorphism of class I major …

Adaptive immunity is based on peptide antigen recognition. Our ability to harness the
immune system for therapeutic gain relies on the discovery of the T cell receptor (TCR) …

Digital nucleic acid analysis technology has shown great application potential due to its
excellent performance. However, most current digital nucleic acid detection methods are …

Digital PCR enabled high-sensitivity and quantitative measurements of rare biological
variants. A new digital droplet-enabled PCR technology was introduced in this paper, which …

Cell-based immunotherapies, such as T cells engineered with chimeric antigen receptors
(CARs), have the potential to cure patients of disease otherwise refractory to conventional …

Adoptive T cell therapies are transforming the treatment of solid and liquid tumors, yet their
widespread adoption is limited in part by the challenge of generating functional cells. T cell …

T cell receptor-engineered T (TCR-T) cell therapies are at the forefront of cancer
immunotherapy, offering a transformative approach that significantly enhances the ability of …