Immunology, already a discipline in its own right, has become a major part of many different
medical fields. However, its relationship to orthopedics and trauma surgery has …

Alloy based implants have made a great impact in the clinic and in preclinical research.
Immune responses are one of the major causes of failure of these implants in the clinic …

Organ‐on‐a‐chip in vitro platforms accurately mimic complex microenvironments offering
the ability to recapitulate and dissect mechanisms of physiological and pathological settings …

Periprosthetic osteolysis (PPO) along with aseptic loosening (AL) caused by wear particles
after artificial joint replacement is the key factor in surgical failure and subsequent revision …

Classically, particle-induced periprosthetic osteolysis at the implant–bone interface has
explained the aseptic loosening of joint replacement. This response is preceded by …

Chronic pain associated with joint disorders, such as rheumatoid arthritis (RA), osteoarthritis
(OA) and implant aseptic loosening (AL), is a highly debilitating symptom that impacts …

Background Different pathologies, affecting the skeletal system, were reported to display
altered bone and/or cartilage innervation profiles leading to the deregulation of the tissue …

Particulate wear debris can trigger pro-inflammatory bone resorption and result in aseptic
loosening. This complication remains major postoperative discomforts and complications for …

Background Concerns on microplastics (MPs) in food are increasing because of our
increased awareness of daily exposure and our knowledge gap on their potential adverse …

Osteoarthritis (OA) is a painful and disabling musculoskeletal disorder, with a large impact
on the global population, resulting in several limitations on daily activities. In OA …