Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
TGF-β: the master regulator of fibrosis
Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …
Cellular and molecular mechanisms of kidney fibrosis
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …
injury or maladaptive repair. It is considered as the underlying pathological process of …
Focal segmental glomerulosclerosis
AZ Rosenberg, JB Kopp - Clinical Journal of the American Society …, 2017 - journals.lww.com
Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease
worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness …
worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness …
Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches
IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …
TGF-β/Smad signaling in renal fibrosis
TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis.
TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects …
TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects …
Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets
Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …
Diverse role of TGF-β in kidney disease
YY Gu, XS Liu, XR Huang, XQ Yu… - Frontiers in cell and …, 2020 - frontiersin.org
Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD).
Transforming growth factor-β (TGF-β) has been long considered as a key mediator of renal …
Transforming growth factor-β (TGF-β) has been long considered as a key mediator of renal …
Targeting TGF-β signaling in kidney fibrosis
Y Isaka - International journal of molecular sciences, 2018 - mdpi.com
Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and
transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating …
transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating …
TGF-β/Smad and renal fibrosis
TT Ma, XM Meng - Renal Fibrosis: Mechanisms and Therapies, 2019 - Springer
Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM) that
disrupts and replaces functional parenchyma, which leads to organ failure. It is known as the …
disrupts and replaces functional parenchyma, which leads to organ failure. It is known as the …