Calcium and excitation-contraction coupling in the heart
Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …
Regulation of mitochondrial ATP production: Ca2+ signaling and quality control
Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …
[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies
Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …
The role of junctophilin proteins in cellular function
SE Lehnart, XHT Wehrens - Physiological reviews, 2022 - journals.physiology.org
Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …
[图书][B] Models of calcium signalling
The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca2+ release
from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to …
from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to …
True molecular scale visualization of variable clustering properties of ryanodine receptors
Signaling nanodomains rely on spatial organization of proteins to allow controlled
intracellular signaling. Examples include calcium release sites of cardiomyocytes where …
intracellular signaling. Examples include calcium release sites of cardiomyocytes where …
Calcium signaling in cardiomyocyte function
G Gilbert, K Demydenko, E Dries… - Cold Spring …, 2020 - cshperspectives.cshlp.org
Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …
Axial tubule junctions control rapid calcium signaling in atria
S Brandenburg, T Kohl, GSB Williams… - The Journal of …, 2016 - Am Soc Clin Investig
The canonical atrial myocyte (AM) is characterized by sparse transverse tubule (TT)
invaginations and slow intracellular Ca2+ propagation but exhibits rapid contractile …
invaginations and slow intracellular Ca2+ propagation but exhibits rapid contractile …
Size matters: ryanodine receptor cluster size affects arrhythmogenic sarcoplasmic reticulum calcium release
Background Ryanodine receptors (RyR) mediate sarcoplasmic reticulum calcium (Ca2+)
release and influence myocyte Ca2+ homeostasis and arrhythmias. In cardiac myocytes …
release and influence myocyte Ca2+ homeostasis and arrhythmias. In cardiac myocytes …