Nucleobase and nucleoside transport and integration into plant metabolism

C Girke, M Daumann, S Niopek-Witz… - Frontiers in plant …, 2014 - frontiersin.org
Nucleotide metabolism is an essential process in all living organisms. Besides newly
synthesized nucleotides, the recycling (salvage) of partially degraded nucleotides, ie …

Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

RP De Vries, R Riley, A Wiebenga, G Aguilar-Osorio… - Genome biology, 2017 - Springer
Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …

[HTML][HTML] Endocytosis of nutrient transporters in fungi: The ART of connecting signaling and trafficking

C Barata-Antunes, R Alves, G Talaia, M Casal… - Computational and …, 2021 - Elsevier
Plasma membrane transporters play pivotal roles in the import of nutrients, including sugars,
amino acids, nucleobases, carboxylic acids, and metal ions, that surround fungal cells. The …

Origin, diversification and substrate specificity in the family of NCS 1/FUR transporters

E Krypotou, T Evangelidis, J Bobonis… - Molecular …, 2015 - Wiley Online Library
NCS 1 proteins are H+/Na+ symporters specific for the uptake of purines, pyrimidines and
related metabolites. In this article, we study the origin, diversification and substrate specificity …

Molecular mechanism of ligand recognition by membrane transport protein, Mhp1

KJ Simmons, SM Jackson, F Brueckner… - The EMBO …, 2014 - embopress.org
The hydantoin transporter Mhp1 is a sodium‐coupled secondary active transport protein of
the nucleobase‐cation‐symport family and a member of the widespread 5‐helix inverted …

Function and regulation of fungal amino acid transporters: Insights from predicted structure

C Gournas, M Prévost, EM Krammer… - Yeast Membrane Transport, 2016 - Springer
Amino acids constitute a major nutritional source for probably all fungi. Studies of model
species such as the yeast Saccharomyces cerevisiae and the filamentous fungus …

Uracil/H+ Symport by FurE Refines Aspects of the Rocking-bundle Mechanism of APC-type Transporters

I Zantza, Y Pyrris, S Raniolo, GF Papadaki… - Journal of Molecular …, 2023 - Elsevier
Transporters mediate the uptake of solutes, metabolites and drugs across the cell
membrane. The eukaryotic FurE nucleobase/H+ symporter of Aspergillus nidulans has been …

Mechanistic basis of pH-dependent 5-flucytosine resistance in Aspergillus fumigatus

F Gsaller, T Furukawa, PD Carr, B Rash… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
ABSTRACT The antifungal drug 5-flucytosine (5FC), a derivative of the nucleobase cytosine,
is licensed for the treatment of fungal diseases; however, it is rarely used as a …

The arrestin‐like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad‐range and specific signals

M Karachaliou, S Amillis, M Evangelinos… - Molecular …, 2013 - Wiley Online Library
We investigated the role of all arrestin‐like proteins of A spergillus nidulans in respect to
growth, morphology, sensitivity to drugs and specifically for the endocytosis and turnover of …

Dissection of transporter function: from genetics to structure

G Diallinas - Trends in Genetics, 2016 - cell.com
Transporters are transmembrane proteins mediating the selective uptake or efflux of solutes,
metabolites, drugs, or ions across cellular membranes. Despite their immense biological …