Towards clinical translation of FLASH radiotherapy
MC Vozenin, J Bourhis, M Durante - Nature Reviews Clinical Oncology, 2022 - nature.com
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
[HTML][HTML] Ultra-high dose rate (FLASH) radiotherapy: Silver bullet or fool's gold?
JD Wilson, EM Hammond, GS Higgins… - Frontiers in …, 2020 - frontiersin.org
Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …
[HTML][HTML] FLASH radiotherapy: current knowledge and future insights using proton-beam therapy
JR Hughes, JL Parsons - International journal of molecular sciences, 2020 - mdpi.com
FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of
magnitude higher than what is currently used in conventional clinical radiotherapy, and has …
magnitude higher than what is currently used in conventional clinical radiotherapy, and has …
Ultra‐high dose rate dosimetry: challenges and opportunities for FLASH radiation therapy
F Romano, C Bailat, PG Jorge, MLF Lerch… - Medical …, 2022 - Wiley Online Library
The clinical translation of FLASH radiotherapy (RT) requires challenges related to dosimetry
and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors …
and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors …
Biological benefits of ultra-high dose rate FLASH radiotherapy: sleeping beauty awoken
MC Vozenin, JH Hendry, CL Limoli - Clinical oncology, 2019 - Elsevier
Abstract FLASH radiotherapy (FLASH-RT) is a technology that could modify the way
radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of …
radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of …
Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review
N Esplen, MS Mendonca… - Physics in Medicine & …, 2020 - iopscience.iop.org
Ultrahigh dose-rate radiotherapy (RT), or'FLASH'therapy, has gained significant momentum
following various in vivo studies published since 2014 which have demonstrated a reduction …
following various in vivo studies published since 2014 which have demonstrated a reduction …
Clinical translation of FLASH radiotherapy: Why and how?
J Bourhis, P Montay-Gruel, PG Jorge, C Bailat… - Radiotherapy and …, 2019 - Elsevier
Over the past decades, technological advances have transformed radiation therapy (RT) into
a precise and powerful treatment for cancer patients. Nevertheless, the treatment of radiation …
a precise and powerful treatment for cancer patients. Nevertheless, the treatment of radiation …
Ultra‐high dose rate electron beams and the FLASH effect: from preclinical evidence to a new radiotherapy paradigm
In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …
The FLASH effect depends on oxygen concentration
G Adrian, E Konradsson, M Lempart… - The British journal of …, 2020 - academic.oup.com
Objective: Recent in vivo results have shown prominent tissue sparing effect of radiotherapy
with ultra-high dose rates (FLASH) compared to conventional dose rates (CONV). Oxygen …
with ultra-high dose rates (FLASH) compared to conventional dose rates (CONV). Oxygen …
A potential revolution in cancer treatment: A topical review of FLASH radiotherapy
FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …