The synapse has emerged as a critical neuronal structure in the degenerative process of
Alzheimer disease (AD), in which the pathogenic signals of two key players—amyloid-β (Aβ) …

Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …

Soluble α-synuclein aggregates varying in size, structure, and morphology have been
closely linked to neuronal death in Parkinson's disease. However, the heterogeneity of …

Protein aggregation is a hallmark of major neurodegenerative disorders. Increasing data
suggest that smaller aggregates cause higher toxic response than filamentous aggregates …

Within condensed matter, single fluorophores are sensitive probes of their chemical
environments, but it is difficult to use their limited photon budget to image precisely their …

Super-resolution microscopy (SRM) technology that breaks the diffraction limit has
revolutionized the field of cell biology since its appearance, which enables researchers to …

Simultaneous measurements of single-molecule positions and orientations provide critical
insight into a variety of biological and chemical processes. Various engineered point spread …

Neurodegenerative diseases such as Alzheimer's and Parkinson's are associated with
protein misfolding and aggregation. Recent studies suggest that the small, rare and …

In the last decade, point accumulation for imaging in nanoscale topography (PAINT) has
emerged as a versatile tool for single-molecule localization microscopy (SMLM). Currently …

Over the past thirty years, researchers have highlighted the role played by a class of proteins
or polypeptides that forms pathogenic amyloid aggregates in vivo, including i) the amyloid …