Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage.
Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein …

Statins are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular
disease (ASCVD). However, even under optimal statin therapy, a significant residual …

Hepatic uptake and biosynthesis of fatty acids (FAs), as well as the partitioning of FAs into
oxidative, storage, and secretory pathways, are tightly regulated processes. Dysregulation of …

Triglycerides are carried in the bloodstream as the components of very low-density
lipoproteins and chylomicrons. These circulating triglycerides are primarily hydrolyzed in …

Atherosclerosis, the major cause of cardiovascular disease, is a chronic inflammatory
disease characterized by the accumulation of lipids and inflammatory cells in the artery wall …

Dyslipidemia, characterized by a high level of lipids (cholesterol, triglycerides, or both), can
increase the risk of developing and progressing atherosclerosis. As atherosclerosis …

The angiopoietin‐like 4 (ANGPTL4) protein belongs to a superfamily of secreted proteins
structurally related to factors modulating angiogenesis known as angiopoietins. At first …

Further determination of ANGPTL4 regulatory circuits and defining specific molecular events
that mediate its biological effects remain key to future ANGPTL4-based therapeutic …

Alterations in circulating lipids and ectopic lipid deposition impact on the risk of developing
cardiovascular and metabolic diseases. Lipoprotein lipase (LPL) hydrolyzes fatty acids (FAs) …

Atherosclerosis, the leading cause of death, is a vascular disease of chronic inflammation.
We recently showed that angiopoietin-like 4 (ANGPTL4) promotes cardiac repair by …