Mu-opioid receptor and receptor tyrosine kinase crosstalk: Implications in mechanisms of opioid tolerance, reduced analgesia to neuropathic pain, dependence, and …

MC Gamble, BR Williams, N Singh, L Posa… - Frontiers in Systems …, 2022 - frontiersin.org
Despite the prevalence of opioid misuse, opioids remain the frontline treatment regimen for
severe pain. However, opioid safety is hampered by side-effects such as analgesic …

Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding

JV Rodarte, C Baehr, D Hicks, TL Liban, C Weidle… - Structure, 2023 - cell.com
Opioid-related fatal overdoses have reached epidemic proportions. Because existing
treatments for opioid use disorders offer limited long-term protection, accelerating the …

Escalated oxycodone self-administration causes differential striatal mRNA expression of FGFs and IEGs following abstinence-associated incubation of oxycodone …

CA Blackwood, M Leary, A Salisbury, MT McCoy… - Neuroscience, 2019 - Elsevier
Addiction to prescribed opioids including oxycodone has reached tragic levels. Herein, we
investigated the relevance of fibroblast growth factors (FGFs) and immediate early genes …

Role of orbitofrontal cortex in incubation of oxycodone craving in male rats

RD Altshuler, ES Yang, KT Garcia, IR Davis… - Addiction …, 2021 - Wiley Online Library
One of the main challenges in treating opioid‐use disorders is relapse during abstinence,
triggered by re‐exposure to drug‐associated cues. Previous studies have demonstrated that …

Role of oestrous cycle and orbitofrontal cortex in oxycodone seeking after 15‐day abstinence in female rats

A Olaniran, RD Altshuler, MAM Burke, H Lin… - Addiction …, 2023 - Wiley Online Library
Relapse to oxycodone seeking progressively increases after abstinence in rats, a
phenomenon termed incubation of oxycodone craving. We have previously shown that the …

Beyond urban centers: Investigating general strain theory and opioid use among rural adolescents

JL Steele, KF Durkin - Journal of Criminal Justice, 2024 - Elsevier
The opioid epidemic has devastated rural America, including adolescents that reside in
these regions, yet studies on that focus on this population remain scarce. This study …

Pregnant women's history of childhood maltreatment and current opioid use: The mediating role of reflective functioning

J Macfie, BJ Zvara, GL Stuart, G Kurdziel-Adams… - Addictive …, 2020 - Elsevier
There is an association between the experience of childhood maltreatment and opioid
misuse in adults, especially for women. However, we know little about this association in …

Preoperative opioid use and incidence of surgical site infection after repair of ventral and incisional hernias

Z Hassan, MJ Nisiewicz, W Ueland, MA Plymale… - Surgery, 2020 - Elsevier
Background Preoperative opioid use is a risk factor for complications after some surgical
procedures. The purpose of this study was to investigate the influence of preoperative …

Do Cochrane reviews reflect the latest evidence on meditation and mindfulness-based interventions? A snapshot of the current evidence

CY Kwon, B Lee, SY Chung, JW Kim - Explore, 2021 - Elsevier
Growing evidence emphasizes the importance of meditation and mindfulness-based
interventions (MBIs) in clinical settings. Here, we attempted to determine the clinical issues …

Correctly identifying deaths due to drug toxicity without a forensic autopsy

DW Dye, G McGwin, DS Atherton… - The American journal …, 2019 - journals.lww.com
Abstract In 2005, the National Association of Medical Examiners approved the Forensic
Autopsy Performance Standards. Standard B3. 7 indicates that a forensic pathologist shall …