Mu-opioid receptor and receptor tyrosine kinase crosstalk: Implications in mechanisms of opioid tolerance, reduced analgesia to neuropathic pain, dependence, and …
Despite the prevalence of opioid misuse, opioids remain the frontline treatment regimen for
severe pain. However, opioid safety is hampered by side-effects such as analgesic …
severe pain. However, opioid safety is hampered by side-effects such as analgesic …
Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding
Opioid-related fatal overdoses have reached epidemic proportions. Because existing
treatments for opioid use disorders offer limited long-term protection, accelerating the …
treatments for opioid use disorders offer limited long-term protection, accelerating the …
Escalated oxycodone self-administration causes differential striatal mRNA expression of FGFs and IEGs following abstinence-associated incubation of oxycodone …
CA Blackwood, M Leary, A Salisbury, MT McCoy… - Neuroscience, 2019 - Elsevier
Addiction to prescribed opioids including oxycodone has reached tragic levels. Herein, we
investigated the relevance of fibroblast growth factors (FGFs) and immediate early genes …
investigated the relevance of fibroblast growth factors (FGFs) and immediate early genes …
Role of orbitofrontal cortex in incubation of oxycodone craving in male rats
RD Altshuler, ES Yang, KT Garcia, IR Davis… - Addiction …, 2021 - Wiley Online Library
One of the main challenges in treating opioid‐use disorders is relapse during abstinence,
triggered by re‐exposure to drug‐associated cues. Previous studies have demonstrated that …
triggered by re‐exposure to drug‐associated cues. Previous studies have demonstrated that …
Role of oestrous cycle and orbitofrontal cortex in oxycodone seeking after 15‐day abstinence in female rats
A Olaniran, RD Altshuler, MAM Burke, H Lin… - Addiction …, 2023 - Wiley Online Library
Relapse to oxycodone seeking progressively increases after abstinence in rats, a
phenomenon termed incubation of oxycodone craving. We have previously shown that the …
phenomenon termed incubation of oxycodone craving. We have previously shown that the …
Beyond urban centers: Investigating general strain theory and opioid use among rural adolescents
The opioid epidemic has devastated rural America, including adolescents that reside in
these regions, yet studies on that focus on this population remain scarce. This study …
these regions, yet studies on that focus on this population remain scarce. This study …
Pregnant women's history of childhood maltreatment and current opioid use: The mediating role of reflective functioning
There is an association between the experience of childhood maltreatment and opioid
misuse in adults, especially for women. However, we know little about this association in …
misuse in adults, especially for women. However, we know little about this association in …
Preoperative opioid use and incidence of surgical site infection after repair of ventral and incisional hernias
Z Hassan, MJ Nisiewicz, W Ueland, MA Plymale… - Surgery, 2020 - Elsevier
Background Preoperative opioid use is a risk factor for complications after some surgical
procedures. The purpose of this study was to investigate the influence of preoperative …
procedures. The purpose of this study was to investigate the influence of preoperative …
Do Cochrane reviews reflect the latest evidence on meditation and mindfulness-based interventions? A snapshot of the current evidence
CY Kwon, B Lee, SY Chung, JW Kim - Explore, 2021 - Elsevier
Growing evidence emphasizes the importance of meditation and mindfulness-based
interventions (MBIs) in clinical settings. Here, we attempted to determine the clinical issues …
interventions (MBIs) in clinical settings. Here, we attempted to determine the clinical issues …
Correctly identifying deaths due to drug toxicity without a forensic autopsy
DW Dye, G McGwin, DS Atherton… - The American journal …, 2019 - journals.lww.com
Abstract In 2005, the National Association of Medical Examiners approved the Forensic
Autopsy Performance Standards. Standard B3. 7 indicates that a forensic pathologist shall …
Autopsy Performance Standards. Standard B3. 7 indicates that a forensic pathologist shall …