Background Trastuzumab is a first‐line targeted therapy for human epidermal growth factor
receptor‐2 (HER2)‐positive gastric cancer. However, the inevitable occurrence of acquired …

The cancer peptidome has long been known to be altered by genetic mutations. However,
more recently, non-genetic polypeptide mutations have also been related to cancer cells …

Protein SUMOylation, a post-translational modification, intricately regulates diverse
biological processes including gene expression, cell cycle progression, signaling pathway …

The progression of non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive
bladder cancer (MIBC) is a major challenge in urologic oncology. However, understanding …

IQ motif containing GTPase activating protein 1 (IQGAP1) is a scaffold protein to transduce
multiple signals from the extracellular microenvironment. However, whether IQGAP1 …

IQGAP1 (IQ motif-containing GTPase-activating protein 1) scaffolds several signaling
pathways in mammalian cells that are implicated in carcinogenesis, including the RAS and …

Lysine lactylation (Kla) plays a vital role in several physiological processes. However, the
cancer‐specific modulation of Kla in gastrointestinal (GI) tumors requires systematic …

Post-translational modifications (PTMs) of proteins contribute to the occurrence and
development of tumors. Previous studies have suggested that canonical PTMs such as …

Acute myeloid leukemia (AML) is fatal in the majority of adults. Identification of new
therapeutic targets and their pharmacologic modulators are needed to improve outcomes …

A constant communication between the nucleus and the mitochondria allows both
organelles to ensure cellular homeostasis and adaptation to mitochondrial stress …