Gastrointestinal redox homeostasis in ageing

J Homolak - Biogerontology, 2023 - Springer
The gastrointestinal (GI) barrier acts as the primary interface between humans and the
external environment. It constantly faces the risk of inflammation and oxidative stress due to …

Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics

J Homolak - Advances in Protein Chemistry and Structural Biology, 2023 - Elsevier
Neurodegenerative diseases are a group of age-related disorders characterized by a
chronic and progressive loss of function and/or structure of synapses, neurons, and glial …

Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose …

J Homolak, A Babic Perhoc, A Knezovic… - …, 2022 - karger.com
Introduction: Gastrointestinal dyshomeostasis is investigated in the context of metabolic
dysfunction, systemic, and neuroinflammation in Alzheimer's disease. Dysfunctional …

Serum-free cultures of C2C12 cells show different muscle phenotypes which can be estimated by metabolic profiling

M Jang, J Scheffold, LM Røst, H Cheon, P Bruheim - Scientific Reports, 2022 - nature.com
In vitro skeletal muscle cell production is emerging in the field of artificial lab-grown meat as
alternative future food. Currently, there is an urgent paradigm shift towards a serum …

Altered secretion, constitution, and functional properties of the gastrointestinal mucus in a rat model of sporadic alzheimer's disease

J Homolak, J De Busscher… - ACS Chemical …, 2023 - ACS Publications
The gastrointestinal (GI) system is affected in Alzheimer's disease (AD); however, it is
currently unknown whether GI alterations arise as a consequence of central nervous system …

The absence of gastrointestinal redox dyshomeostasis in the brain-first rat model of Parkinson's disease induced by bilateral intrastriatal 6-hydroxydopamine

J Homolak, M Joja, G Grabaric, E Schiatti, D Virag… - Molecular …, 2024 - Springer
The gut-brain axis plays an important role in Parkinson's disease (PD) by acting as a route
for vagal propagation of aggregated α-synuclein in the gut-first endophenotype and as a …

The effect of acute oral galactose administration on the redox system of the rat small intestine

J Homolak, A Babic Perhoc, A Knezovic… - Antioxidants, 2021 - mdpi.com
Galactose is a ubiquitous monosaccharide with important yet incompletely understood
nutritive and physiological roles. Chronic parenteral d-galactose administration is used for …

Failure of the brain glucagon-like peptide-1-mediated control of intestinal redox homeostasis in a rat model of sporadic Alzheimer's disease

J Homolak, A Babic Perhoc, A Knezovic… - Antioxidants, 2021 - mdpi.com
The gastrointestinal system may be involved in the etiopathogenesis of the insulin-resistant
brain state (IRBS) and Alzheimer's disease (AD). Gastrointestinal hormone glucagon-like …

D-galactose might protect against ionizing radiation by stimulating oxidative metabolism and modulating redox homeostasis

J Homolak, A Babic Perhoc, D Virag… - Journal of Radiation …, 2023 - academic.oup.com
Dear Editor, We read with great interest a recent study by Zhu et al.[1], which suggests that
repeated parenteral administration of D-galactose (750 mg/kg/day) exerts protective effects …

Insights into Gastrointestinal Redox Dysregulation in a Rat Model of Alzheimer's Disease and the Assessment of the Protective Potential of D-Galactose

J Homolak, K Varvaras, V Sciacca, A Babic Perhoc… - ACS …, 2024 - ACS Publications
Recent evidence suggests that the gut plays a vital role in the development and progression
of Alzheimer's disease (AD) by triggering systemic inflammation and oxidative stress. The …