Coordination of the cell cycle in trypanosomes
RJ Wheeler, K Gull, JD Sunter - Annual review of microbiology, 2019 - annualreviews.org
Trypanosomes have complex life cycles within which there are both proliferative and
differentiation cell divisions. The coordination of the cell cycle to achieve these different …
differentiation cell divisions. The coordination of the cell cycle to achieve these different …
Life in plastic, it's fantastic! How Leishmania exploit genome instability to shape gene expression
Leishmania are kinetoplastid pathogens that cause leishmaniasis, a debilitating and
potentially life-threatening infection if untreated. Unusually, Leishmania regulate their gene …
potentially life-threatening infection if untreated. Unusually, Leishmania regulate their gene …
FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres
X Pan, WC Drosopoulos, L Sethi… - Proceedings of the …, 2017 - National Acad Sciences
In the mammalian genome, certain genomic loci/regions pose greater challenges to the
DNA replication machinery (ie, the replisome) than others. Such known genomic loci/regions …
DNA replication machinery (ie, the replisome) than others. Such known genomic loci/regions …
Transcriptionally driven DNA replication program of the human parasite Leishmania major
R Lombraña, A Álvarez, JM Fernández-Justel… - Cell reports, 2016 - cell.com
Faithful inheritance of eukaryotic genomes requires the orchestrated activation of multiple
DNA replication origins (ORIs). Although origin firing is mechanistically conserved, how …
DNA replication origins (ORIs). Although origin firing is mechanistically conserved, how …
Shining a spotlight on DNA: single-molecule methods to visualise DNA
The ability to watch single molecules of DNA has revolutionised how we study biological
transactions concerning nucleic acids. Many strategies have been developed to manipulate …
transactions concerning nucleic acids. Many strategies have been developed to manipulate …
Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe
CA Marques, NJ Dickens, D Paape, SJ Campbell… - Genome biology, 2015 - Springer
Background DNA replication initiates on defined genome sites, termed origins. Origin usage
appears to follow common rules in the eukaryotic organisms examined to date: all …
appears to follow common rules in the eukaryotic organisms examined to date: all …
Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal …
Background Trypanosoma brucei is a unicellular parasite which multiplies in mammals
(bloodstream form) and Tsetse flies (procyclic form). Trypanosome RNA polymerase II …
(bloodstream form) and Tsetse flies (procyclic form). Trypanosome RNA polymerase II …
Differences in the detection of BrdU/EdU incorporation assays alter the calculation for G1, S, and G2 phases of the cell cycle in trypanosomatids
Trypanosomatids are the etiologic agents of various infectious diseases in humans. They
diverged early during eukaryotic evolution and have attracted attention as peculiar models …
diverged early during eukaryotic evolution and have attracted attention as peculiar models …
[HTML][HTML] Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems
In trypanosomatids, etiological agents of devastating diseases, replication is robust and
finely controlled to maintain genome stability and function in stressful environments …
finely controlled to maintain genome stability and function in stressful environments …
Read, write, adapt: challenges and opportunities during kinetoplastid genome replication
The genomes of all organisms are read throughout their growth and development,
generating new copies during cell division and encoding the cellular activities dictated by …
generating new copies during cell division and encoding the cellular activities dictated by …