Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

Alzheimer's disease (AD) is a neurodegenerative disorder that causes cognitive decline,
memory loss, and inability to perform everyday functions. Hallmark features of AD …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Despite tremendous investments in understanding the complex molecular mechanisms
underlying Alzheimer disease (AD), recent clinical trials have failed to show efficacy. A …

Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

The β‐amyloid precursor protein (APP) has been extensively studied for its role as the
precursor of the β‐amyloid protein (Aβ) of Alzheimer's disease. However, the normal …

The β‐site APP cleaving enzymes 1 and 2 (BACE 1 and BACE 2) were initially identified as
transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE 1 is …

Biochemical and genetic evidence establishes a central role of the amyloid precursor
protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β …

For 20 years the amyloid cascade hypothesis of Alzheimer disease (AD) has placed the
amyloid-β peptide (Aβ), formed from the amyloid precursor protein (APP), centre stage in the …