Regulation of pain and itch by TRP channels
Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …
pain perception. In this review, we discuss important experimental evidence involving some …
Control of stem cell fate by physical interactions with the extracellular matrix
A diverse array of environmental factors contributes to the overall control of stem cell activity.
In particular, new data continue to mount on the influence of the extracellular matrix (ECM) …
In particular, new data continue to mount on the influence of the extracellular matrix (ECM) …
Mammalian TRP ion channels are insensitive to membrane stretch
TRP channels of the transient receptor potential ion channel superfamily play an important
role in a wide variety of mechanosensory processes, including touch sensation, pain, blood …
role in a wide variety of mechanosensory processes, including touch sensation, pain, blood …
Physiology of cell volume regulation in vertebrates
EK Hoffmann, IH Lambert… - Physiological …, 2009 - journals.physiology.org
The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …
TRP channels
K Venkatachalam, C Montell - Annu. Rev. Biochem., 2007 - annualreviews.org
Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …
remarkable in that it displays greater diversity in activation mechanisms and selectivities …
Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
For mesenchymal stem cells (MSCs) cultured in three dimensional matrices, matrix
remodeling is associated with enhanced osteogenic differentiation. However, the …
remodeling is associated with enhanced osteogenic differentiation. However, the …
Vanilloid receptor–related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
W Liedtke, Y Choe, MA Martí-Renom, AM Bell… - Cell, 2000 - cell.com
The detection of osmotic stimuli is essential for all organisms, yet few osmoreceptive
proteins are known, none of them in vertebrates. By employing a candidate-gene approach …
proteins are known, none of them in vertebrates. By employing a candidate-gene approach …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
The functions of TRPA1 and TRPV1: moving away from sensory nerves
ES Fernandes, MA Fernandes… - British journal of …, 2012 - Wiley Online Library
The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively)
channels are members of the TRP superfamily of structurally related, non‐selective cation …
channels are members of the TRP superfamily of structurally related, non‐selective cation …
The TRP superfamily of cation channels
C Montell - Science's STKE, 2005 - science.org
The transient receptor potential (TRP) protein superfamily consists of a diverse group of
cation channels that bear structural similarities to Drosophila TRP. TRP channels play …
cation channels that bear structural similarities to Drosophila TRP. TRP channels play …