The application of natural killer cell immunotherapy for the treatment of cancer

K Rezvani, RH Rouce - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are essential components of the innate immune system and play a
critical role in host immunity against cancer. Recent progress in our understanding of NK cell …

Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells

M Carlsten, M Järås - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells are large granular lymphocytes involved in our defense against
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …

[HTML][HTML] Leukemia-induced phenotypic and functional defects in natural killer cells predict failure to achieve remission in acute myeloid leukemia

K Stringaris, T Sekine, A Khoder, A Alsuliman… - …, 2014 - ncbi.nlm.nih.gov
The majority of patients with acute myeloid leukemia will relapse, and older patients often
fail to achieve remission with induction chemotherapy. We explored the possibility that …

Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses

J Hilpert, L Grosse-Hovest, F Grünebach… - The journal of …, 2012 - journals.aai.org
Ligands of the prototypical activating NK receptor NKG2D render cancer cells susceptible to
NK cell-mediated cytolysis if expressed at sufficiently high levels. However, malignant cells …

Decreased expression of DNAM‐1 on NK cells from acute myeloid leukemia patients

B Sanchez‐Correa, I Gayoso… - Immunology and cell …, 2012 - Wiley Online Library
This study tested the hypothesis that the expression of CD112 and CD155 (DNAM‐1
ligands) on leukemic blasts induces a decreased expression of the activating receptor …

Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors

AS Fairey, KS Courneya, CJ Field… - Journal of Applied …, 2005 - journals.physiology.org
The objective was to determine the effects of exercise training on changes in blood immune
function in postmenopausal breast cancer survivors. Fifty-three postmenopausal breast …

NK cells in the tumor microenvironment

SK Larsen, Y Gao, PH Basse - Critical Reviews™ in …, 2014 - dl.begellhouse.com
The presence of natural killer (NK) cells in the tumor microenvironment correlates with
outcome in a variety of cancers. However, the role of intratumoral NK cells is unclear …

γδT cells elicited by CMV reactivation after allo-SCT cross-recognize CMV and leukemia

W Scheper, S van Dorp, S Kersting, F Pietersma… - Leukemia, 2013 - nature.com
Human cytomegalovirus (CMV) infections and relapse of disease remain major problems
after allogeneic stem cell transplantation (allo-SCT), in particular in combination with CMV …

The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia

RH Rouce, H Shaim, T Sekine, G Weber, B Ballard… - Leukemia, 2016 - nature.com
Natural killer (NK) cells are key components of the innate immune system, providing potent
antitumor immunity. Here, we show that the tumor growth factor-β (TGF-β)/SMAD signaling …

CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia

SJ Coles, ECY Wang, S Man, RK Hills, AK Burnett… - Leukemia, 2011 - nature.com
Upregulation of the immunosuppressive cell surface glycoprotein, CD200, is a common
feature of acute myeloid leukemia (AML) and is associated with poor patient outcome. We …