High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis

NSL Yeo-Teh, Y Ito, S Jha - International journal of molecular sciences, 2018 - mdpi.com
Infection with high-risk human papillomavirus (HPV) has been linked to several human
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …

Head and neck cancer

A Argiris, MV Karamouzis, D Raben, RL Ferris - The Lancet, 2008 - thelancet.com
Most head and neck cancers are squamous cell carcinomas that develop in the upper
aerodigestive epithelium after exposure to carcinogens such as tobacco and alcohol …

Epigenetics of aging and disease: a brief overview

C Pagiatakis, E Musolino, R Gornati… - Aging clinical and …, 2021 - Springer
Aging is an important risk factor for several human diseases such as cancer, cardiovascular
disease and neurodegenerative disorders, resulting from a combination of genetic and …

Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression

SA Selamat, BS Chung, L Girard, W Zhang… - Genome …, 2012 - genome.cshlp.org
Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its
most common histological subtype. Clinical and molecular evidence indicates that lung …

Eurogin Roadmap: comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix

ML Gillison, X Castellsagué… - … journal of cancer, 2014 - Wiley Online Library
The EUROGIN 2012 roadmap is focused on the comparative epidemiology of human
papillomavirus (HPV) associated head and neck squamous cell cancers (HNSCC) and …

RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis

SM Gupta, J Mania-Pramanik - Journal of biomedical science, 2019 - Springer
Cervical cancer is the fourth most frequent cancer in women worldwide and a major cause of
mortality in developing countries. Persistent infection with high-risk human papillomavirus …

Human papillomaviruses-associated cancers: an update of current knowledge

E Pešut, A Đukić, L Lulić, J Skelin, I Šimić… - Viruses, 2021 - mdpi.com
Human papillomaviruses (HPVs), which are small, double-stranded, circular DNA viruses
infecting human epithelial cells, are associated with various benign and malignant lesions of …

Genomic risk factors for cervical cancer

D Ramachandran, T Dörk - Cancers, 2021 - mdpi.com
Simple Summary Cervical cancer is the fourth leading cause of cancer-related deaths in
females worldwide. Despite an active immunisation strategy in many countries, high-risk …

Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation

AE Teschendorff, A Jones, H Fiegl, A Sargent… - Genome medicine, 2012 - Springer
Background Recently, it has been proposed that epigenetic variation may contribute to the
risk of complex genetic diseases like cancer. We aimed to demonstrate that epigenetic …

Clinical, morphologic and molecular heterogeneity of HPV-associated oropharyngeal cancer

YX Lim, ML Mierzwa, MA Sartor, NJ D'Silva - Oncogene, 2023 - nature.com
The incidence of human papillomavirus-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) is rising rapidly and has exceeded cervical cancer to become the most …