DNA hypermethylation in disease: mechanisms and clinical relevance

M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Neurobiology of early life adversity: A systematic review of meta-analyses towards an integrative account of its neurobiological trajectories to mental disorders

Y Hakamata, Y Suzuki, H Kobashikawa… - Frontiers in …, 2022 - Elsevier
Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of developing mental disorders in later life. However, no review has …

Gut microbiome-wide association study of depressive symptoms

D Radjabzadeh, JA Bosch, AG Uitterlinden… - Nature …, 2022 - nature.com
Depression is one of the most poorly understood diseases due to its elusive pathogenesis.
There is an urgency to identify molecular and biological mechanisms underlying depression …

Objectives, design and main findings until 2020 from the Rotterdam Study

MA Ikram, G Brusselle, M Ghanbari… - European journal of …, 2020 - Springer
Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

EWAS Atlas: a curated knowledgebase of epigenome-wide association studies

M Li, D Zou, Z Li, R Gao, J Sang, Y Zhang… - Nucleic acids …, 2019 - academic.oup.com
Abstract Epigenome-Wide Association Study (EWAS) has become increasingly significant in
identifying the associations between epigenetic variations and different biological traits. In …

A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci

NA Kimbrel, AE Ashley-Koch, XJ Qin, JH Lindquist… - Molecular …, 2022 - nature.com
To identify pan-ancestry and ancestry-specific loci associated with attempting suicide among
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …

Origins of human disease: the chrono-epigenetic perspective

ES Oh, A Petronis - Nature Reviews Genetics, 2021 - nature.com
Epigenetics has enriched human disease studies by adding new interpretations to disease
features that cannot be explained by genetic and environmental factors. However …

Ten years of EWAS

S Wei, J Tao, J Xu, X Chen, Z Wang, N Zhang… - Advanced …, 2021 - Wiley Online Library
Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation
variation in complex diseases for a decade, and epigenome as a research target has …

Transcriptomic decoding of regional cortical vulnerability to major depressive disorder

J Zhu, X Chen, B Lu, XY Li, ZH Wang, LP Cao… - Communications …, 2024 - nature.com
Previous studies in small samples have identified inconsistent cortical abnormalities in
major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is …

Epigenetic prediction of major depressive disorder

MC Barbu, X Shen, RM Walker, DM Howard… - Molecular …, 2021 - nature.com
Variation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking
and body mass index (BMI) but there has been little research exploring its ability to identify …