DNA hypermethylation in disease: mechanisms and clinical relevance
M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …
malignant diseases. This is consistent with numerous findings about differentiation …
Neurobiology of early life adversity: A systematic review of meta-analyses towards an integrative account of its neurobiological trajectories to mental disorders
Y Hakamata, Y Suzuki, H Kobashikawa… - Frontiers in …, 2022 - Elsevier
Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of developing mental disorders in later life. However, no review has …
increasing the risk of developing mental disorders in later life. However, no review has …
Gut microbiome-wide association study of depressive symptoms
D Radjabzadeh, JA Bosch, AG Uitterlinden… - Nature …, 2022 - nature.com
Depression is one of the most poorly understood diseases due to its elusive pathogenesis.
There is an urgency to identify molecular and biological mechanisms underlying depression …
There is an urgency to identify molecular and biological mechanisms underlying depression …
Objectives, design and main findings until 2020 from the Rotterdam Study
MA Ikram, G Brusselle, M Ghanbari… - European journal of …, 2020 - Springer
Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …
EWAS Atlas: a curated knowledgebase of epigenome-wide association studies
Abstract Epigenome-Wide Association Study (EWAS) has become increasingly significant in
identifying the associations between epigenetic variations and different biological traits. In …
identifying the associations between epigenetic variations and different biological traits. In …
A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci
NA Kimbrel, AE Ashley-Koch, XJ Qin, JH Lindquist… - Molecular …, 2022 - nature.com
To identify pan-ancestry and ancestry-specific loci associated with attempting suicide among
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …
veterans, we conducted a genome-wide association study (GWAS) of suicide attempts within …
Origins of human disease: the chrono-epigenetic perspective
ES Oh, A Petronis - Nature Reviews Genetics, 2021 - nature.com
Epigenetics has enriched human disease studies by adding new interpretations to disease
features that cannot be explained by genetic and environmental factors. However …
features that cannot be explained by genetic and environmental factors. However …
Ten years of EWAS
S Wei, J Tao, J Xu, X Chen, Z Wang, N Zhang… - Advanced …, 2021 - Wiley Online Library
Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation
variation in complex diseases for a decade, and epigenome as a research target has …
variation in complex diseases for a decade, and epigenome as a research target has …
Transcriptomic decoding of regional cortical vulnerability to major depressive disorder
J Zhu, X Chen, B Lu, XY Li, ZH Wang, LP Cao… - Communications …, 2024 - nature.com
Previous studies in small samples have identified inconsistent cortical abnormalities in
major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is …
major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is …
Epigenetic prediction of major depressive disorder
Variation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking
and body mass index (BMI) but there has been little research exploring its ability to identify …
and body mass index (BMI) but there has been little research exploring its ability to identify …